en Genetics & Disease Genetics & Disease Case Report Case Report <p style="text-align: justify;">Beta thalassemia is the&nbsp; most common autosomal recessive disorder. The present study reports a rare &beta; globin gene mutation, HBB: c.180G>A: codon 59 (AAG/AAA), in a patient from Gilan province, northern Iran. Nucleotide sequencing of amplified DNA belonging to a 35 years old man presenting mild hypochromia revealed a synonymous mutation due to a G>A conversion at the third position of codon 59 of the beta globin gene. The haplotype combination of 2 restriction enzyme sites in beta globin cluster was determined for this mutation. To our knowledge, this is the first article reporting a synonymous mutation&nbsp; at codon 59 (G>A) among the Iranian population highlighting once again the high heterogeneity of this population.</p> Beta globin, HBB: c.180G>A mutation, Iran 164 166 http://ibbj.org/browse.php?a_code=A-10-35-3&slc_lang=en&sid=1 Haleh Akhavan-Niaki halehakhavan@yahoo.com 10031947532846001814 10031947532846001814 Yes Reza Youssefi Kamangari 10031947532846001815 10031947532846001815 No Ali Banihashemi 10031947532846001816 10031947532846001816 No Mandana Azizi 10031947532846001817 10031947532846001817 No