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:: Volume 5, Issue 1 (Int Biol Biomed J (In press) 2019) ::
IBBJ 2019, 5(1): 0-0 Back to browse issues page
Circulating miR-193b-3p and miR-376a-3p Involved in Iranian Patients with Multiple Sclerosis
Behnaz Nateghi1, Farzaneh Emadi2, Mosayeb Eghbali2, Pouriya Pezeshki2, Amir Eshaghiyan *3
1- Department of Biochemistry, Faculty of Science, Nourdanesh Institutions of Higher Education, Meimeh, Isfahan, Iran.
2- Department of Genetics, Arsanjan Branch, Islamic Azad University, Arsanjan, Shiraz, Iran.
3- Department of Genetics, Arsanjan Branch, Islamic Azad University, Arsanjan, Shiraz, Iran. , amireashaghiyan@gmail.com
Abstract:   (982 Views)
Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system. MicroRNAs (miRNAs) are small non-coding RNAs that are usually 18-24 nucleotides long, which may have a pivotal role in the expansion of many complex diseases. The objective of this study was to evaluate the transcript levels of miR-193b-3p and miR-376a-3p in relapsing-remitting multiple sclerosis (RRMS) patients. In this case-control study, miR-193b-3p and miR-376a-3p expression in 60 RRMS patients, of which 30 were recurring patients and 30 were two months after relapse patients, and 30 healthy subjects were examined in peripheral blood mononuclear cells using real-time PCR reaction. Our results showed that the expression of miR-193b-3p was significantly reduced in recurring patients and two months after relapse patients in comparison with healthy subjects (P < 0.004 and P < 0.0001, respectively). In contrast, miR-376a-3p showed an increased expression in recurring patients and two months after relapse patients (P < 0.0001). Based on the findings, it can be assumed that miR-193b-3p and miR-376a-3p may be prospective biomarkers with the potential use for diagnosis of RRMS patients.
Keywords: Multiple sclerosis, biomarker, miRNA, miR-193b-3p, miR-376a-3p
Full-Text [PDF 527 kb]   (158 Downloads)    
Type of Study: Original Article | Subject: Genetics & Disease
Received: 2019/03/13 | Accepted: 2019/04/25 | Published: 2019/05/23
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Nateghi B, Emadi F, Eghbali M, Pezeshki P, Eshaghiyan A. Circulating miR-193b-3p and miR-376a-3p Involved in Iranian Patients with Multiple Sclerosis. IBBJ. 2019; 5 (1)
URL: http://ibbj.org/article-1-220-en.html


Volume 5, Issue 1 (Int Biol Biomed J (In press) 2019) Back to browse issues page
International Biological and Biomedical Journal
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