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Potential Anti-obesity Effects of some Medicinal Herb: In vitro α-Amylase, α-Glucosidase and Lipase Inhibitory Activity
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Edris Ardeshirlarijani1   , Nazli Namazi2 , Reza B Jalili3 , Mina Saeedi4 , Somaye Imanparast5 , Hamid-Reza Adhami6 , Mohammad Ali Faramarzi6 , Mohammad Hossein Ayati7 , Mohammad Mahdavi8 , Bagher Larijani * 9 |
1- Simon Fraser University, Vancouver, Canada.
2- Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
3- Burn and Wound Healing Laboratory, Department of Surgery, Division of Plastic Surgery, University of British Columbia, Vancouver, BC, Canada.
4- Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
5- Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
6- Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
7- Department of Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
8- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
9- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran. , larijanib1340@gmail.com |
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Abstract: (6765 Views) |
In this study, in vitro inhibitory activity of methanolic and chloroform extracts of some medicinal plants including C. wightii, T. ammi, N. sativa, C. arabica, L. usitatissimum, C. cyminum, and R. Graveolens was evaluated toward α-glucosidase, α-amylase, and lipase comparing with acarbose and orlistat as the standard inhibitors. Our results revealed that both methanolic and chloroform extracts of C.wightii depicted high activity toward α-glucosidase (IC50s = 100.2 and 110.3 µg/mL, respectively) while methanolic and chloroform extracts of R.graveolens as well as chloroform extract of C.arabica showed good to moderate inhibitory activity (IC50s = 281.0, 460.5, and 280.0 µg/mL, respectively). Among the evaluated extracts, methanolic extract of R.graveolens and chloroform extract of C.arabica were found to be potent inhibitors toward α-amylase (IC50s = 215.0 and 180.0 µg/mL, respectively). However, moderate activity was obtained by methanolic and chloroform extracts of C. wightii and chloroform extract of R.graveolens (IC50 = 273.5, 358.5, and 479.0 µg/mL). It should be noted that all extracts demonstrated no significant inhibitory activity against lipase. |
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| Keywords: α-amylase, obesity, α-glucosidase, lipase, medicinal plants |
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Full-Text [PDF 942 kb]
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Type of Study: Original Article |
Subject:
Other
Received: 2019/06/5 | Accepted: 2019/07/2 | Published: 2019/08/14
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Ardeshirlarijani E, Namazi N, B Jalili R, Saeedi M, Imanparast S, Adhami H, et al . Potential Anti-obesity Effects of some Medicinal Herb: In vitro α-Amylase, α-Glucosidase and Lipase Inhibitory Activity. IBBJ 2019; 5 (2) URL: http://ibbj.org/article-1-228-en.html
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