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Laboratory Parameters and Anthropometry of Sickle Cell Disease Patients at Two Childhood Stages
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AA Iyanda *1   , Anuoluwapo Alaka2 |
1- Ladoke Akintola University of Technology, Ogbomoso , lapeiyanda@yahoo.com
2- Adeleke University, Ede |
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Abstract: (300 Views) |
| The physiological state can impact the presentation of diseases, yet intra-childhood differences in the presentation of sickle cell disease (SCD) remain unexplored among pediatric patients in Osun State, Nigeria. This study aimed to determine how anthropometric measurements and levels of zinc, packed cell volume (PCV), and nitric oxide (NO) differ in children with SCD during the first and second halves of childhood. Pediatric patients aged 3-17 years were recruited from public health facilities in Osun State and classified based on childhood stage (first or second half). Levels of zinc, PCV, and NO, along with anthropometric measurements, were determined using standard techniques. Data were analyzed using analysis of variance (ANOVA) and LSD post hoc tests, with a significance level set at p < 0.05. Regardless of childhood stage, levels of zinc, NO, PCV, body weight, mid-upper arm circumference (MUAC), and body mass index (BMI) were significantly different when comparing the control group with the SCD groups. In the first half of childhood, only PCV and zinc levels differed significantly between HbSS and HbSC participants, while in the second half, all parameters (except body weight and head circumference) were significantly different between HbSS and HbSC. SCD negatively impacts anthropometric parameters and levels of zinc, PCV, and NO. Furthermore, the data suggest that the severity of the disease is similar for HbSC and HbSS during the first half of childhood but appears more pronounced for HbSS than HbSC during the second half. |
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| Keywords: Childhood stages, Zn, nitric oxide, anthropometry and hemoglobinopathy |
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Type of Study: Original Article |
Subject:
Clinical Biochemistry
Received: 2024/06/11 | Accepted: 2024/09/25 | Published: 2024/10/12
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