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:: Volume 9, Issue 2 (7-2023) ::
IBBJ 2023, 9(2): 0-0 Back to browse issues page
The wound healing effect of fish scales isolated collagen sponge along with Eisenia foetida glycolipoprotein extract (G-90) in foot ulcer of diabetic rat
Maryam M. Elmi1 , Fatemeh Elmi2 , Chiman Ghaderi3 , Farideh Feizi * 4
1- Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran
2- Department of Marine Chemistry, Faculty of Marine & oceanic sciences, University of Mazandaran, Babolsar, Iran
3- Department of Radiation Technology, Paramedical Faculty, Babol University of Medical Sciences, Babol, Iran
4- Department of Anatomical Science, and Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Science, Babol, Iran , feizi.dr@gmail.com
Abstract:   (681 Views)
Treatment of diabetic ulcers is associated with a failure in wound healing. While collagen dressing was applied effectively in wound healing, today, advanced dressing designs that can accelerate healing has received attention. Tissue homogenates glycolipoprotein (G-90) contains some growth factors that can participate in healing. The present study examined the wound healing effects of fish scale collagen sponge along with G-90 on sutured incisions in diabetic rats. G-90 was isolated from earthworm (Eisenia foetida). Type 1 collagen was purified from fish scales and lyophilized in sponge form. The sponges were immersed in 10 ng of G- 90. The efficacy of collagen sponge/G-90 was evaluated on sutured incisions in STZ-induced diabetic rats on days 4, 8, 14, and 18 through a morphological and histological approach. The results demonstrated that collagen sponge/G-90 is effective as a wound healing accelerator all days after wounding. Re-epithelialization and angiogenesis were significantly better in the treated group with collagen sponge/G-90 (P≤0.05). Experimental data demonstrated that collagen sponge/G-90 increased fibroblast proliferation, vascularization, collagen synthesis, and collagen fibril diameters. Considering the existence of many growth factors in G-90 and the role of collagen in the extracellular matrix, we conclude that the collagen sponge/G-90 could be a natural mixture for the management of wound healing. Additional studies are proposed to approve it as a wound-healing agent.
Keywords: collagen sponge, G-90, diabetic rat, earthworm, wound healing
Full-Text [PDF 787 kb]   (90 Downloads)    
Type of Study: Original Article | Subject: Other
Received: 2022/07/3 | Accepted: 2023/01/27 | Published: 2024/02/29
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Elmi M M, Elmi F, Ghaderi C, Feizi F. The wound healing effect of fish scales isolated collagen sponge along with Eisenia foetida glycolipoprotein extract (G-90) in foot ulcer of diabetic rat. IBBJ 2023; 9 (2)
URL: http://ibbj.org/article-1-277-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 9, Issue 2 (7-2023) Back to browse issues page
International Biological and Biomedical Journal
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