:: Volume 3, Issue 4 (Int Biol Biomed J 2017) ::
IBBJ 2017, 3(4): 157-161 Back to browse issues page
Treacher Collins Syndrome
Ambarkova Vesna *
Department of Pediatric and Preventive Dentistry, Faculty of Dental Medicine, St. Cyril and Methodius University, Skopje, Republic of Macedonia. , vesna.ambarkova@gmail.com
Abstract:   (7934 Views)
Treacher Collins syndrome (TCS) is a genetic disease that alters the development of bones and other tissues in the face, and presents variable expressivity. At least three genes TCOF1, POLR1D, and POLR1C were recognized to be at the origin of this syndrome which may be inherited through either an autosomal dominant or autosomal recessive pattern. TCS changes can be divided into otological, ophthalmic and dental malformations. Dental abnormalities occur in 60% of cases and may appear as  tooth agenesis, enamel opacities, widely-spaced teeth, skeletal open bite, distalization of the mandible, bird profile, ectopic eruption of maxillary first molars, improper positioning of the teeth and jaw, and hypoplasia of the mandible jaw. Receding chin and other changes in face structure can be corrected by plastic surgery. As multiple body systems are affected in TCS, long-term follow-up care and the collaboration of a multidisciplinary team care is necessary in order to achieve better physical and psychosocial performances.
Keywords: Treacher Collins syndrome, craniofacial defects, treatment, genetic
Full-Text [PDF 305 kb]   (6238 Downloads)    
Type of Study: Mini Review | Subject: Genetics & Disease
Received: 2017/04/14 | Accepted: 2017/07/1 | Published: 2017/08/26

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Volume 3, Issue 4 (Int Biol Biomed J 2017) Back to browse issues page