:: Volume 4, Issue 1 (Int Biol Biomed J 2018) ::
IBBJ 2018, 4(1): 48-53 Back to browse issues page
In vivo Antiplasmodial and Cytotoxic Activity of Achyranthes aspera and Ficus thoningii in Mice Infected with Plasmodium berghei
Moses Zaruwa 1, Joshua Osuigwe Madu * 2, Abdulhakeem Adebayo Yusuf 3, Abdurrasheed Ola Ola Muhammed 4
1- Department of Biochemistry, Adamawa State University, Mubi, Nigeria.
2- Department of Chemistry, American University of Nigeria, Yola, Nigeria. , joshuamadu11@gmail.com
3- Microbiology Unit, Medical Laboratory Services Department, Federal Medical Centre, Yola, Nigeria.
4- Usmanu DanfodiyDepartment of Histopathology, Faculty of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.o University, Sokoto
Abstract:   (1556 Views)
Malaria remains o n e o f the leading causes of morbidity and mortality in tropical countries, and the alarming spread of the drugs resistant malaria parasite underscores the need to develop new antimalarial compounds. In this study, the phytochemical constituents, in vivo antiplasmodial, and cytotoxic activity of methanolic extracts of Achyranthes aspera and Ficus thoningii were evaluated using chloroquine sensitive Plasmodium berghei in mice. The extract of F. thoningii exhibited significant (P˂0.05) blood schizontocidal activity a dose dependent manner; in a four day treatment test. Likewise, A. aspera extract resulted in high suppressions of schizonts (74%, 100% and 87%) at 50, 100, and 200 mg/Kg body weight, respectively (P˂0.05). Neither death nor toxic signs was recorded in the mice in the acute toxicity study. These findings provide scientific rationale for the traditional use of these plants against malaria symptoms, and also make the plant a candidate for bioactivity guided phytochemical analyzes to identify the active principles.
Keywords: Malaria, Ficus thoningii, Achyranthes aspera, antiplasmodial activity
Full-Text [PDF 348 kb]   (398 Downloads)    
Type of Study: Original Article | Subject: Pharmacology
Received: 2017/08/21 | Accepted: 2017/10/22 | Published: 2017/11/22

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Volume 4, Issue 1 (Int Biol Biomed J 2018) Back to browse issues page