Recent pre-clinical and clinical studies have revealed the C-reactive protein gene (CRP) is related to the degree of acute rise in plasma C-reactive protein (CRP) levels. Moreover, single nucleotide polymorphisms (SNPs) in the CRP gene could associate with increased risk of cancer, atherosclerosis, diabetes mellitus, bowel disease, rheumatoid arthritis, psoriasis, obstructive pulmonary disease, periodontitis, nonalcoholic fatty liver disease and cardiovascular (CV) diseases. Less is known about the role of variabilities of circulating levels of CRP due to SNPs as an individual biological marker of CV risk and poor clinical outcomes due to CV reasons. The results of clinical trials and some meat-analysis are controversial in this issue. The short commentary is depicted the possible role of SNPs in CRP gene as a personified biological marker of CV risk. It has concluded that the inconsistent results in determination of the predictive role of SNPs in CRP gene as a biological marker of CV disease and CV events require more investigations.