:: Volume 4, Issue 2 (Int Biol Biomed J 2018) ::
IBBJ 2018, 4(2): 122-125 Back to browse issues page
The Single Nucleotide Polymorphisms in the C-reactive Protein Gene: are they Biomarkers of Cardiovascular Risk?
Alexander Berezin *
Internal Medicine Department of Internal Medicine, State Medical University for Zaporozhye, Zaporozhye, Ukraine. , aeberezin@gmail.com
Abstract:   (1671 Views)
Recent pre-clinical and clinical studies have revealed the C-reactive protein gene (CRP) is related to the degree of acute rise in plasma C-reactive protein (CRP) levels. Moreover, single nucleotide polymorphisms (SNPs) in the CRP gene could associate with increased risk of cancer, atherosclerosis, diabetes mellitus, bowel disease, rheumatoid arthritis, psoriasis, obstructive pulmonary disease, periodontitis, nonalcoholic fatty liver disease and cardiovascular (CV) diseases. Less is known about the role of variabilities of circulating levels of CRP due to SNPs as an individual biological marker of CV risk and poor clinical outcomes due to CV reasons. The results of clinical trials and some meat-analysis are controversial in this issue. The short commentary is depicted the possible role of SNPs in CRP gene as a personified biological marker of CV risk. It has concluded that the inconsistent results in determination of the predictive role of SNPs in CRP gene as a biological marker of CV disease and CV events require more investigations.
Keywords: Cardiovascular risk, biological markers, C-reactive protein, single nucleotide polymorphisms, prognosis, prediction
Full-Text [PDF 330 kb]   (379 Downloads)    
Type of Study: Short Communication | Subject: Clinical Medicine
Received: 2018/01/14 | Accepted: 2018/02/4 | Published: 2018/03/4

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Volume 4, Issue 2 (Int Biol Biomed J 2018) Back to browse issues page