Recently, there is a growing interest to use the alternative medicine and natural therapies in the treatment of toxicity. Flavonoids are one of these natural therapies that were used by researchers in the treatment of some intoxication cases. Naringenin is the most influential flavonoids wherein it is found in citrus fruits such as orange, grapefruit, and mandarin. Naringenin is considered a potent natural antioxidant in vitro and in vivo. It can be hepatoprotective, renoprotective, cardioprotective, neuroprotective, and cytoprotective in many cases of toxicity besides its ability in amelioration the testicular and developmental toxicity. Its efficacy depends on the capability to scavenge strongly the free radicals such as superoxide and hydroxyl radicals preventing the oxidative stress toxicity and lipid peroxidation.