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Ferula Assafoetida Extract Prevents Acetaminophen-induced Hepatotoxicity in Mice
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Elyas Khayatzadeh1    , Firouz Faedmaleki * 2 |
1- Faculty of Veterinary Medicine, Babol Branch, Islamic Azad University, Babol, Iran
2- Department of Pharmacology, Babol Branch, Islamic Azad University, Babol, Iran , faedmalekif@yahoo.com |
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Abstract: (2089 Views) |
Background and aims: In recent years due to the daily usage of large amounts of chemical drugs, more attention has been paid to the effect of plants on the treatment and prevention of poisoning caused by these drugs. Herbaceous Ferula assafoetida has antioxidant and anti-inflammatory properties. In this study, the protective effect of Ferula assafoetida hydroalcoholic extract (Fer) on acetaminophen-induced liver toxicity was investigated.
Materials and methods: 42 mice weighing 25-30 g were randomly divided into six groups. The control group received normal saline and the treatment group gavaged Fer every 12 hours for 7 days 50, 100, 200mg/kg BW and a single dose of acetaminophen (Ace) 500 mg/kg on the 6th day. One other group received only Ace at a dose of 500 mg/kg BW as intraperitoneally (IP) on the 6th day, and the last group received only Fer (250mg/kg) orally for one week every 12 hours. At the end of the study (8th day), Blood was collected by heart puncture, and serum was separated to measure biochemical indices and liver tissues fixed in 10% formalin buffer. One-way ANOVA and Tukey's analysis at the significance level of P<0.05 were used to analyze data.
Results: Fer significantly decreased AST, ALT, ALP, T. bilirubin parameters and significantly increased Alb in experimental groups compared to the acetaminophen group.
Conclusion: According to the results of this study, Fer has a protective role in hepatotoxicity caused by acetaminophen. |
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| Keywords: Ferula assafoetida, Acetaminophen, Liver poisoning |
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Type of Study: Original Article |
Subject:
Clinical Biochemistry
Received: 2022/02/7 | Accepted: 2022/03/10 | Published: 2022/03/10
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