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The Effect of Aqueous Extract of Citrullus Lanatus Seed on the Kidney and Liver in Alcohol-Induced Toxicity in Male Rats
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Obed Chinwendu Aralu1   , A.A Nwankwo1 , Emmanuel Nonso Ezeokafor2 , Chibueze Jeremiah Ike3 , Roy Uchefuna2 , Kester Nwaefulu2 , Kelechi Collins Onwuka4 , Augustine wisdom Ehimen5 , Chikwesiri Emmanuel Onyema * 6 |
1- Dept of physiology, faculty of basic medical science, Abia state uturu
2- Department of physiology faculty of basic medical science Nnamdi Azikiwe university
3- department of pharmacology and toxicology, faculty of pharmaceutical science Nnamdi Azikiwe university Ajulu campus.
4- Department of physiology faculty of basic medical science Abia state uturu
5- department of pharmacology and toxicology faculty of pharmaceutical science.
6- Department of physiology faculty of basic medical science Nnamdi Azikiwe university , cemmanuelonyema@gmail.com |
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Abstract: (267 Views) |
Alcohol abuse and alcoholism are serious health and socioeconomic problems globally, and chronic alcohol intake can spawn abundant reactive oxygen species (ROS), including superoxide anion radical, hydroxyl radical, and hydrogen peroxide. The study aims to ascertain the impact of an aqueous extract of Citrullus lanatus seed on Liver enzymes, urea and creatinine and following alcohol-induced toxicity in male Wistar rats. The animals were divided into five groups of six animals each, as follows: Group A served as a positive control and received feed and water only; Group B served as a negative control and received alcohol only; Group C received 500 mg/kg of ASCL for 6 weeks; Group D received 3 ml of alcohol for 3 weeks and was treated with 500 mg/kg of ASCL for 6 weeks; and Group E received 3 ml of alcohol for 3 weeks and was treated with 1000 mg/kg of ASCL for 6 weeks. The experiment lasted for 9 weeks, and administration was done through oral gavage. The alcohol-only treated group had a significant difference (p=o.oo) when compared to the normal control, and a significant difference (p=o.oo) was seen in the alcohol-only treated group in comparison with ASCL-treated groups for kidney function, and liver enzymes. Liver enzymes AST, ALT, and ALP in the findings showed a marked increase, indicating an incidence of liver damage. Urea and creatinine were also high in alcohol treated groups. The liver and kidney complications were both attenuated by ASCL, as evidenced by the sharp decline in liver enzymes, urea, and creatinine.
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| Keywords: Citrullus lanatus, Alcohol-induced toxicity, kidney function, liver enzymes. |
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Type of Study: Original Article |
Subject:
Other
Received: 2024/05/12 | Accepted: 2024/06/11 | Published: 2024/06/11
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