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Benzimidazole Derivatives as Multitarget Agents: Synthesis, Characterization, Invitro Alpha-glucosidase Inhibition and Antioxidants Activity
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چکیده: (2851 مشاهده) |
Nitrogen-containing compounds, specifically benzimidazole derivatives, represent a significant class of molecules with diverse biological properties that have garnered considerable attention in medicinal chemistry. In this study, two 2-substituted benzimidazoles were successfully synthesized using a boric acid-catalyzed method. The resulting products demonstrated good yields and sharp melting points. The structures of the synthesized compounds were elucidated using Fourier-transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy, including both proton (¹H-NMR) and carbon (¹³C-NMR) analyses.The compounds were evaluated for their alpha-glucosidase inhibitory activity and antioxidant properties. Both compounds exhibited notable antidiabetic and antioxidant activities. Notably, the compound designated as BL24 demonstrated the highest alpha-glucosidase inhibitory activity and radical scavenging properties. These experimental results indicate that benzimidazoles possess effective antidiabetic and antioxidant potential. |
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نوع مطالعه: Original Article |
موضوع مقاله:
Other
دریافت: 1403/7/8 | پذیرش: 1403/9/3 | انتشار: 1403/10/9
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