Urtica dioica is a perennial plant used as herbal medicine due to its many pharmacological and clinical effects. Because of its antioxidant activity, it is widely used in traditional diabetes treatment but is also known as antimicrobial, anti inflammatory or anti prostate cancer agent. Extensive studies have been conducted on different parts of this plant and their biological effects. Here we reviewed the effect of different parts of this plant including leave, seed, root and aerial part extracted with various methods in treatment of diseases. Various beneficial effects were reported on animal models without apparent side effects, which led us to consider it as an emerald to be more deeply discovered in the kingdom of health.