en Cancer Cancer Mini Review Mini Review <p style="text-align: justify;">The colorectal cancer (CRC) subtyping consortium has unified six independent molecular classification systems, based on gene expression data, into a single consensus system with four distinct groups, known as the consensus molecular subtypes (CMS); clinical implications are discussed in this review based on articles relevant to the CMS of CRC indexed in PubMed as well as the authors&rsquo; own published data. The CMS were determined and correlated with epigenomic, transcriptomic, microenvironmental, genetic, prognostic and clinical characteristics. The CMS1 subtype is immunogenic and hypermutated. CMS2 tumors are activated by the WNT-&beta;-catenin pathway and have the highest overall survival. CMS3 feature a metabolic cancer phenotype and CMS4 cancers have the worst survival and have a strong stromal gene signature. The CMS of CRC may better inform clinicians of prognosis, therapeutic response, and potential novel therapeutic strategies.</p> Colorectal cancer, molecular subtypes, clinical, classification 105 111 http://ibbj.org/browse.php?a_code=A-10-221-1&slc_lang=en&sid=1 Ketan Thanki kethanki@utmb.edu 10031947532846002776 10031947532846002776 No Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. Michael Edward Nicholls mienicho@utmb.edu 10031947532846002777 10031947532846002777 No Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. Guillermo Gomez ggomez@utmb.edu 10031947532846002778 10031947532846002778 No Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. Aakash Gajjar aagajjar@utmb.edu 10031947532846002779 10031947532846002779 No Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. Anthony James Senagore ajsenago@utmb.edu 10031947532846002780 10031947532846002780 No Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. Laila Rashidi larashid@utmb.edu 10031947532846002781 10031947532846002781 No Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. Suimin Qiu sqiu@utmb.edu 10031947532846002782 10031947532846002782 No Department of Surgical Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. Csaba Szabo csszabo@utmb.edu 10031947532846002783 10031947532846002783 No Department of Anesthesiology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. Mark Richard Hellmich mhellmic@utmb.edu 10031947532846002784 10031947532846002784 No Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. Celia Chao cechao@utmb.edu 10031947532846002785 10031947532846002785 Yes Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.