en Other Other Original Article Original Article <div style="text-align: justify;">In this study, <em>in vitro </em>inhibitory activity of methanolic and chloroform extracts of some medicinal plants including<em> C. wightii</em>, <em>T. ammi</em>, <em>N. sativa</em>, <em>C. arabica</em>, <em>L. usitatissimum</em>, <em>C. cyminum</em>, and <em>R. Graveolens </em>was evaluated toward &alpha;-glucosidase, &alpha;-amylase, and lipase comparing with acarbose and orlistat as the standard inhibitors. Our results revealed that both methanolic and chloroform extracts of <em>C.wightii </em>depicted high activity toward &alpha;-glucosidase (IC₅₀s = 100.2 and 110.3 &micro;g/mL, respectively) while methanolic and chloroform extracts of <em>R.graveolens </em>as well as chloroform extract of <em>C.arabica </em>showed good to moderate inhibitory activity (IC₅₀s = 281.0, 460.5, and 280.0 &micro;g/mL, respectively). Among the evaluated extracts, methanolic extract of <em>R.graveolens </em>and chloroform extract of <em>C.arabica</em> were found to be potent inhibitors toward &alpha;-amylase (IC₅₀s = 215.0 and 180.0 &micro;g/mL, respectively). However, moderate activity was obtained by methanolic and chloroform extracts of <em>C. wightii </em>and chloroform extract of <em>R.graveolens </em>(IC₅₀ = 273.5, 358.5, and 479.0 &micro;g/mL). It should be noted that all extracts demonstrated no significant inhibitory activity against lipase.</div> α-amylase, obesity, α-glucosidase, lipase, medicinal plants 0 0 http://ibbj.org/browse.php?a_code=A-10-348-1&slc_lang=en&sid=1 Edris Ardeshirlarijani ediardeshir@gmail.com 10031947532846003744 10031947532846003744 No Simon Fraser University, Vancouver, Canada. Nazli Namazi nazli.namazi@yahoo.com 10031947532846003745 10031947532846003745 No Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Reza B Jalili rjalili@mail.ubc.ca 10031947532846003746 10031947532846003746 No Burn and Wound Healing Laboratory, Department of Surgery, Division of Plastic Surgery, University of British Columbia, Vancouver, BC, Canada. Mina Saeedi m-saeedi@tums.ac.ir 10031947532846003747 10031947532846003747 No Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Somaye Imanparast so_imanparast@ut.ac.ir 10031947532846003748 10031947532846003748 No Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Hamid-Reza Adhami hr-adhami@tums.ac.ir 10031947532846003749 10031947532846003749 No Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Ali Faramarzi faramarz@tums.ac.ir 10031947532846003750 10031947532846003750 No Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Hossein Ayati ayatimd@gmail.com 10031947532846003751 10031947532846003751 No Department of Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Mahdavi mahdavi_chem@yahoo.com 10031947532846003752 10031947532846003752 No Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Bagher Larijani larijanib1340@gmail.com 10031947532846003753 10031947532846003753 Yes Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.