en Clinical Medicine Clinical Medicine Mini Review Mini Review The present paper refers to some of the most critical aspects of the management of adult-T cell leukaemia/lymphoma (ATL), which is a rare malignancy that affect the 5-7% of infected with human T cell-lymphotropic virus-1 (HTLV-1). ATL has a geographical distribution that includes countries such as Japan, the Caribbean, Central and South America and sub-Saharan Africa. The ATL management includes the use of antivirals, monoclonal antibodies, chemotherapy, radiotherapy, hematopoietic stem cell transplantation (HSCT) and more modern experimental approach, which are promising as immunotherapy. Despite available therapy the prognosis  of ATL remains poor, but it may improve in the upcoming years with the parallel advancement in the basic medical sciences. Adult-T cell leukaemia/lymphoma, Management, Cancer, Hematopoietic stem cell transplantation (HSCT), Immunotherapy 0 0 http://ibbj.org/browse.php?a_code=A-10-296-4&slc_lang=en&sid=1 Angel Justiz Vaillant angel.vaillant@sta.uwi.edu 10031947532846003803 10031947532846003803 Yes University of the West Indies. St. Augustine