en Stem Cell Stem Cell Review Review <span style="font-size:11pt"><span style="line-height:200%"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Transparency of the cornea as a clear window on the front surface of the eye is an important issue in visual system that a number of ocular surface diseases affect this. The human ocular surface is constructed by two various types of epithelia: the corneal epithelium in center and the conjunctival epithelium that surrounds this. These two epithelia are </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">separated by limbal epithelium which is known as a major source of stem cells.</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> The limbal stem cells (LSCs) provide the source of corneal epithelial renewal and also provide a promising approach to treat chronic epithelial defects on the corneal surface. Therefore, this review summarizes the current knowledge regarding to cornea and ocular surface diseases with special focusses on stem-cell-based therapeutic methods to improve and restore sight in affected patients. </span></span></span></span></span></span></span><br> &nbsp; Limbal stem cell, Ocular surface disease, corneal homeostasis 0 0 http://ibbj.org/browse.php?a_code=A-10-391-1&slc_lang=en&sid=1 Seyed Ahmad Rasoulinejad rasolisa2@gmail.com 10031947532846004142 10031947532846004142 No Department of Ophthalmology, School of Medicine, Babol University of Medical Sciences, Babol, IR, Iran Nooshin Sarreshtehdari nooshin.sar20@gmail.com 10031947532846004143 10031947532846004143 No Student Research Committee, Qazvin University of Medical Sciences, Qazvin, IR, Iran. Amir Reza Mafi amirrezamafi1992@gmail.com 10031947532846004144 10031947532846004144 Yes Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IR, Iran.