International Biological and Biomedical Journal
IBBJ
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Effect of Aqueous Extract of Telfairia Occidentalis and Amaranthus Hybridus L. on Cortisol, Malondialdehyde, and Total Antioxidant Capacity Levels of Adult Male Wistar Rats Exposed to Chronic Physical Restraint Stress
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Original Article
Original Article
<span style="font-size:11pt"><span style="line-height:normal !msorm"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm">hronic stress is known to trigger several physiological alterations; a lack of significant adaptation can </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">lead to</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> serious </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">issues</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> in physiological well-being. </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">Vegetables are natural sources of phytochemical components and possess antioxidant capabilities</span></span></span><strong><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="color:#0e101a !msorm">.</span></span></span></strong> <span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm">This study aimed to evaluate the </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">effects</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> of aqueous leaf </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">extracts</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> of</span></span></span></span> <em><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="color:#0e101a !msorm"><span style="font-weight:normal !msorm">Telfairia occidentalis</span></span></span></span></em> <span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm">and</span></span></span></span> <em><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="color:#0e101a !msorm"><span style="font-weight:normal !msorm">Amaranthus hybridus</span></span></span></span></em> <span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm">on cortisol, malondialdehyde (MDA), and </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">total</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> antioxidant capacity (TAC) levels </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">in</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> adult male Wistar rats exposed to chronic physical restraint stress.</span></span></span></span> <span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm">A total of 25 male Wistar rats were used, grouped into five </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">categories</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> (A, B, C, D, E). Groups A and B served as the positive and negative control groups, </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">respectively; </span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm">both control groups received feed and water, </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">while</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> group </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">B</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> (negative control</span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">) was subjected to</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> stress </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">without</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> extract</span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"> treatment. Groups</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> C, D, and E were all subjected to stress </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">via</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> physical restraint for 42 days</span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">.</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> Group C received </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">500 mg</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm">/kg of</span></span></span></span> <em><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="color:#0e101a !msorm"><span style="font-weight:normal !msorm">Telfairia occidentalis</span></span></span></span></em><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> extract, group D received </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">500 mg</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm">/kg of</span></span></span></span> <em><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="color:#0e101a !msorm"><span style="font-weight:normal !msorm">Amaranthus hybridus</span></span></span></span></em><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> extract, and </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">group</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> E received both </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">extracts (500 mg</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm">/kg </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">each)</span></span></span><em><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="color:#0e101a !msorm"><span style="font-style:normal !msorm"> for 21 days</span></span></span></span></em><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm">. </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">Data were analyzed using ANOVA followed by post-hoc LSD comparison, with significance set at </span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="font-style:italic !msorm"><span style="font-weight:normal !msorm">P<0.05</span></span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">. Results indicated that stress significantly increased MDA levels, while groups C, D, and E showed significant decreases in MDA levels after receiving the extracts. However, t</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm">he extracts </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">did not significantly affect</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> cortisol levels. The study suggests that </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"><span style="font-style:italic !msorm"><span style="font-weight:normal !msorm">Telfairia occidentalis</span></span></span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> and </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"><span style="font-style:italic !msorm"><span style="font-weight:normal !msorm">Amaranthus hybridus</span></span></span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> extracts </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">may serve</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> as natural </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">remedies</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> for combating oxidative stress by reducing malondialdehyde levels and </span></span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm">enhancing</span></span></span><span style="font-size:12.0pt !msorm"><span style="line-height:107% !msorm"><span style="font-family:"Times New Roman",serif !msorm"><span style="color:#0e101a !msorm"> total antioxidant capacity.</span></span></span></span></span></span></span>
Telfairia Occidentalis, Amaranthus Hybridus, Cortisol, Malondialdehyde, Total Antioxidant Capacity
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http://ibbj.org/browse.php?a_code=A-10-418-2&slc_lang=en&sid=1
Emmanuel
Onyema
cemmanuelonyema@gmail.com
10031947532846004339
10031947532846004339
Yes