en Cancer Cancer Review Review <p style="text-align: justify;">The epigenetic alterations like histone modifications , DNA methylation and others remarkable categories&nbsp; including nucleosome remodeling and RNA mediated targeting have been strongly investigated&nbsp; recently .In this way , beside the notable importance of DNA methylation ,the histone modifications are the most important issues in the&nbsp; tumorogenesis and cancer progression. Moreover, the fluctuations of histone modifications particularly, the dysregulation of histone alterations is engaged directly in carcinogenesis. Conclusively, it is confirmed that aberrant epigenetic modifications along side with chromosomal losses and mutations are involved in cancer progression. Hence, histone modifications and DNA methylation have the impressive abilities and potential to be practical prognostic biomarkers in order to manage all aspects of cancers like diagnosis, controlling and treatment. In this review article, we focus the recent advances of these alterations specially, histone modifications in gastric cancer development.</p> Histone modifications, gastric cancer, DNA methylation, epigenetic 128 136 http://ibbj.org/browse.php?a_code=A-10-35-4&slc_lang=en&sid=1 Seyedeh Elham Norollahi 10031947532846001792 10031947532846001792 No Mohamad Taghi Hamidian 10031947532846001793 10031947532846001793 No Mohaddese Shokravi 10031947532846001794 10031947532846001794 No Mehrnaz Ajourlou 10031947532846001795 10031947532846001795 No Ali Akbar Samadani 10031947532846001796 10031947532846001796 Yes