International Biological and Biomedical Journal
IBBJ
Medical Sciences
http://ibbj.org
1
admin
2423-4478
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7
14
2423
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en
jalali
1395
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1
gregorian
2016
9
1
2
1
online
1
fulltext
en
Expression Analysis of Let-7a miRNA and its Target Gene NRAS in Cytogenetically Normal Family with Myelodysplastic Syndrome
Genetics & Disease
Genetics & Disease
Original Article
Original Article
<p style="text-align: justify;">Myelodysplastic syndrome (MDS), is a group of heterogeneous disorders of hematopoietic stem cell colonies which is determined by incomplete hematopoiesis in one or more cell lines. The incidence increases with age and it has less been reported among patients under 50 years of age. The commonest form of MDS is sporadic, and familial occurrence of MDS is rare. Patients with familial MDS are younger at the time of diagnosis than individuals with sporadic disease and are faced with an unusual family history of more than one first-degree relative with MDS. In this study, we investigated a family with 16 members which has a family history of MDS in three consecutive generations. Cytogenetic and chromosome analyzes were performed on the 16 members of the family. Moreover, let-7a miRNA expression and its target gene, NRAS were evaluated compared to the control group. The karyotype analysis in this family shows two patients with abnormal karyotype, whereas expression of the let-7a and NRAS in this family showed a significant decrease compared to the control group. Regarding the decreased expression of let-7a in patient samples, this miRNA can be further considered as a marker for early diagnosis of MDS disease.</p>
Myelodysplastic syndrome, Familial MDS, Cytogenetic, let-7a, NRAS
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38
http://ibbj.org/browse.php?a_code=A-10-87-3&slc_lang=en&sid=1
Shermineh
Heydari
shermine_heydari@yahoo.com
10031947532846001831
10031947532846001831
No
Elaheh
Ghods
ghods.elahe69@gmail.com
10031947532846001832
10031947532846001832
No
Majid
Mojarrad
MojaradM@mums.ac.ir
10031947532846001833
10031947532846001833
No
Zahra
Mozaheb
mozahebz@mums.ac.ir
10031947532846001834
10031947532846001834
No
Ehsan
Ghayoor Karimiani
ghayoure@mums.ac.ir
10031947532846001835
10031947532846001835
No
Mohammad
Hassanzadeh Nazarabadi
NazarabadiM@mums.ac.ir
10031947532846001836
10031947532846001836
Yes