en Other Other Original Article Original Article <p style="text-align: justify;">The <em>Acacia seyal</em> Dell family Mimosaceaeis is known locally as Talha tree. Many medicinal uses such as treatment of dysentery, leprosy, colds, diarrhea, hemorrhage, ophthalmic, intestinal ailments, rheumatic pains, colds and fevers, have been attributed to this tree. Schistosomiasis, a water-borne parasitic disease caused by Schistosome(s) a genus of digenetic trematode worms, infects man and animals in tropical and sub tropical regions. It is the second most prevalent parasitic disease in the world ranked only after malaria regarding the number of people infected and those at risk. More than 90% of the cases are occurring in Africa. The purpose of this study was to investigate the molluscicidal activiat ty of <em>Acacia seyal</em> bark methanolic extract against the snail <em>Biomphlaria pfeiffer</em>. Different concentrations (1000, 500, 250, 125, 62.5, 31.25, 15.625, 7.8125 and 3.91 ppm) of the <em>Acacia seyal</em> bark methanolic extract, were investigated <em>in vitro</em>&nbsp; against snail <em>Biomphlaria Pfeiffer.</em> <em>A. seyal </em>bark methanolic extract exhibited 100% mortality within 24 h, only at a concentration of 1000 ppm; and&nbsp; exhibited 100% mortality within 48 h, at 1000, 500, 250, 125 and 62.5 ppm. The IC₅₀ of bark of <em>A. seyal </em>at 24 h and 48 h was 80.79 and 34.33 ppm, respectively. These findings prove the potent <em>in vitro</em> activity of <em>A. seyal </em>(bark) methanolic extract against <em>Biomphlaria pfeiffer</em>.</p> Molluscicidal activity, Acacia seyal (bark), Biomphlaria snails, in vitro, Sudan 73 79 http://ibbj.org/browse.php?a_code=A-10-137-1&slc_lang=en&sid=1 Mohamed Abdelsalam Ismail 10031947532846001867 10031947532846001867 No Waleed Sayed Koko 10031947532846001868 10031947532846001868 No El-badri Elamin Osman elbadri150@yahoo.com 10031947532846001869 10031947532846001869 No Mahmoud Mohamed Dahab 10031947532846001870 10031947532846001870 No Mohammed Ismail Garbi 10031947532846001871 10031947532846001871 No Alsadeg Mohamed Alsadeg 10031947532846001872 10031947532846001872 No Ahmed Saeed Kabbashi ahmedsak88@gmail.com 10031947532846001873 10031947532846001873 Yes