en Pharmacology Pharmacology Original Article Original Article <p style="text-align: justify;">Physalis angulata is a medicinal plant used for the treatment of malaria, ulcer, pains and other diverse ailments. The present study evaluated the analgesic and anti-inflammatory activity of methanolic leaf extract of the plant. Acetic acid-induced abdominal contraction or writhing analgesic models in Swiss albino mice (13-23g) were used for studying analgesic activity of the leaf extract. 200, 300 and 400 mg/kg body weight of the extract were administered intraperitoneally. Analgesic activities of the extract were compared with standard reference drug ibuprofen (100 mg/kg) and negative control. The plant extract showed a significant dose dependent analgesic effect, with 72.7% inhibition at 400 mg/kg compared to that of the 100 mg/kg standard drug ibuprofen which showed 21.2% inhibition (P< 0.05). The anti-inflammatory activity of the extract against carrageenan-induced paw edema was also dose-dependent with 62.71% inhibition at 400 mg/kg when compared to that of the standard drug with 34.31% inhibition. The study showed that P. angulata was effective in pain reduction (analgesia) and acted as a good anti-inflammatory agent, which supports the claim in traditional medicine.</p> Physalis angulata, analgesic, anti-inflammatory, Carrageenan 167 170 http://ibbj.org/browse.php?a_code=A-10-106-3&slc_lang=en&sid=1 Cletus Anes Ukwubile doccletus@yahoo.com 10031947532846002315 10031947532846002315 Yes Ikpefan Emmanuel Oise ikpefan@delsu.edu.ng 10031947532846002316 10031947532846002316 No