@article{ author = {Tari, Kaveh and Rahimi, Arezou and Atashi, Amir and Pourfathollah, Ali Akbar and Mesdaghi, Mehrnaz}, title = {Biology of TH17 Lymphocytes, their Cytokines and Role in Disease}, abstract ={T lymphocytes that are involved in cellular mediated immunity include two types known as TCD8+ (Cytotoxic T lymphocytes) and TCD4+ (helper T lymphocytes). TCD4+ has four main subtypes, including TH1, TH2, TH17, and Treg Lymphocytes.TH17 lymphocytes play a role in defense against microbes that TH1 and TH2 lymphocytes have not the ability to respond to them. The most important cytokines, which are involved in induction of this subtype are the tumor growth factor &beta(TGF &beta) and interleukin 6(IL-6), and IL-17 is the most important cytokine, which is released by TH17 cells. IL-17 is the member of the cytokine family, which includs IL-17A-F and among them IL-17A and IL-17F are responsible for biological functions in this cytokine family that have most hemology together rather than other members. Also, TH17 cells produce and release other cytokine such as IL-21, IL-22 and IL-23, which may have the role in functional mechanisms of TH17 lymphocytes. Because of the TH17 lymphocytes roles in the defense against microbes and inflammatory reactions, it seems that TH17 lymphocytes may has a role in inflammatory disorders. The relationship between TH17 lymphocytes and diseases such as Asthma, Psoriasis, Systemic lupus erythematosus (SLE), Rheumatoid Arthritis(RA) and inflammatory bowel disease was shown. In this article, we review the TH17 lymphocytes, their released cytokines and their roles in different autoimmunre and inflammatory diseases.}, Keywords = { TH17 lymphocytes, Cytokine, Function, Disease.}, volume = {1}, Number = {2}, pages = {46-55}, publisher = {4}, url = {http://ibbj.org/article-1-36-en.html}, eprint = {http://ibbj.org/article-1-36-en.pdf}, journal = {International Biological and Biomedical Journal}, issn = {2423-4478}, eissn = {}, year = {2015} } @article{ author = {Ahmadi, Ali Asghar and Shadifar, Mohammad and Ataee, Ramin and Vaillancourt, Cathy and Ataee, Amin and Oufkir, Talal and Jafari-Sabet, Maji}, title = {The Serotonin 5-HT2A Receptor Antagonist Ritanserin Induces Apoptosis in Human Colorectal Cancer and Acts in Synergy with Curcumin}, abstract ={Curcumin exhibits both cancer- preventive activity and growth inhibitory effects on several neoplastic cells including human colon cancer. Serotonin and its receptors have also been implicated in tumor development. This study investigated the effect of ritanserin, a selective serotonin 5HT2A receptor antagonist, alone and in combination with curcumin on colorectal cancer cell lines. Results show that the expression of the serotonin 5HT2A receptor is higher in tumor than in normal colorectal tissues. Ritanserin, reduced cell viability in a dose-dependent manner, and increased apoptosis in HT29, SW480 and SW742 colorectal cancer cell lines as analyzed by MTT and TUNEL assays, respectively. Moreover, combined with curcumin, ritanserin synergistically increased the number of hypodiploid cells and DNA fragmentation and decreased cell viability in all colorectal cancer cell lines. This study demonstrates that curcumin and ritanserin have a synergic anti- mitogenic and apoptotic effect on colorectal cancer cell lines. These results suggest a potential use of serotonin 5HT2A receptor antagonist in co- treatment with curcumin in colon cancer therapy.}, Keywords = {Colon cancer, serotonin 5HT2A receptor, cell growth, ritanserin, TUNEL assay}, volume = {1}, Number = {2}, pages = {56-65}, publisher = {4}, url = {http://ibbj.org/article-1-34-en.html}, eprint = {http://ibbj.org/article-1-34-en.pdf}, journal = {International Biological and Biomedical Journal}, issn = {2423-4478}, eissn = {}, year = {2015} } @article{ author = {EsmaeiliDooki, Mohammad Reza and Akhavan-Niaki, Haleh and Shabani, Soraya and Tabaripour, Rez}, title = {Molecular screening of R117H mutation in non caucasian cystic fibrosis patients in the north of Iran}, abstract ={Cystic fibrosis is an autosomal recessive disease caused by a wide spectrum of mutations in the gene encoding for the cystic fibrosis transmembrane conductance regulator protein. These mutations that correlate with different phenotypes, vary in their frequency and distribution in different populations. In this study missense mutation R117H that associated with the different clinical symptoms was analyzed in CF patients. Fifty five non relative Iranian cystic fibrosis patients aged between four month to eighteen years old living in the north of Iran, Mazandaran province were screened for clinical presentation and also for R117H mutation by reverse dot blot method. the most clinical presentation was pulmonary disorder and non of the patients had R117H mutation these finding will be use in genotypes and phenotypes correlation and planning genetic counseling.}, Keywords = {cystic fibrosis, phenotype, R117H, Reverse Dot Blot}, volume = {1}, Number = {2}, pages = {66-71}, publisher = {4}, url = {http://ibbj.org/article-1-35-en.html}, eprint = {http://ibbj.org/article-1-35-en.pdf}, journal = {International Biological and Biomedical Journal}, issn = {2423-4478}, eissn = {}, year = {2015} } @article{ author = {Fattahi, Sadegh and Yousefi, Gholam Ali and Amirbozorgi, Galia and Lotfi, Maryam and Naeiji, Ali and Asouri, Mohsen and Kavosian, Saeid and Hayati, Effat and Ahmadi, Ali Asghar and Akhavan-Niaki, haleh}, title = {Lack of Association of CYP2E1 and CYP1A1 Polymorphisms With Osteoporosis in Postmenauposal Women}, abstract ={Osteoporosis is a metabolic bone disease affecting mostly elderly women. As metabolizing enzymes, the roles of few cytochromes have been studied in osteoporosis development. The aim of this study was to assess for the first time the association of CYP2E1 and CYP1A1 polymorphisms and osteoporosis in postmenopausal women. 112 postmenopausal women presenting osteoporosis and 93 age and sex matched healthy controls originating from north Iran were enrolled in this study. Rs2031920 and rs3813867 at CYP2E1 as well as rs4646421 and rs2198843 at CYP1A1 loci were studied in all subjects using polymerase chain reaction and restriction fragment length polymorphism analysis. Genotype analysis for rs2031920 showed that the CT genotype was present only in osteoporotic patients with a frequency of 4.17%. Similarly GC genotype at rs3813867 locus was present only in osteoporotic patients with a frequency of 3.13%. [G T] and [C C] haplotypes for rs3813867- rs2031920 were found with low frequencies only in osteoporotic patients. TT genotype at rs4646421 locus was higher in osteoporotic (8.05%) versus control subjects (3.22%), 14.28% of cases were homozygous for the C allele at rs2198843 locus which is higher than controls (11.84%). The [C G] haplotype for rs4646421- rs2198843 was predominant in cases (54.47%) and controls (58.6%). GT haplotype was rare in both groups. No significant differences in genotypes or haplotypes frequencies were observed among the osteoporotic and normal subjects. CYP1A1 and CYP2E1 loci are not associated to osteoporosis risk in the studied population.}, Keywords = {Osteoporosis, CYP1A1, CYP2E1, polymorphism}, volume = {1}, Number = {2}, pages = {72-80}, publisher = {4}, url = {http://ibbj.org/article-1-38-en.html}, eprint = {http://ibbj.org/article-1-38-en.pdf}, journal = {International Biological and Biomedical Journal}, issn = {2423-4478}, eissn = {}, year = {2015} } @article{ author = {Ashour, Mohammed J and Sharif, Fadel A}, title = {The Single Nucleotide Polymorphism rs2305957 is not Associated with Recurrent Pregnancy Loss}, abstract ={This study was conducted in order to investigate the association between the single nucleotide polymorphism (SNP) rs2305957 G/A and recurrent pregnancy loss (RPL) in a group of Palestinian women residing in Gaza strip. A retrospective case-control study was carried out during the period of May to August 2015. A total of 380 females including 190 recurrent pregnancy loss (RPL) patients and 190 control women without previous history of RPL, aged 20–35 years were included in the study. The SNP was analyzed by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR). No statistically significant difference was found between RPL cases and controls in terms of allelic and genotypic distribution of rs2305957 G/A. SNP rs2305957 G/A does not represent a risk factor for RPL in the investigated population.}, Keywords = {Recurrent pregnancy loss (RPL), rs2305957, single nucleotide polymorphism (SNP), Gaza Strip, Palestine}, volume = {1}, Number = {2}, pages = {81-83}, publisher = {4}, url = {http://ibbj.org/article-1-50-en.html}, eprint = {http://ibbj.org/article-1-50-en.pdf}, journal = {International Biological and Biomedical Journal}, issn = {2423-4478}, eissn = {}, year = {2015} } @article{ author = {JavadianKotenaie, Maryam and Yazdani, Shahla and Akram, Sadat and Bouzari, Zinatossadat}, title = {Evaluation of Quality of Life and Menopausal Symptoms in Women with Breast Cancer in Northern Iran}, abstract ={Breast cancer is one of the most common cancers in women and includes approximately 23% of all kinds of cancer. The main reason for evaluation of quality of life (QOL) is to access informations which result in improvement of treatment and health status of patients. The main purpose of this study was to determine menopause symptoms and QOLin postmenopausal patients with breast cancer. Eighty postmenopausal women with history of breast cancer and aged between 45-65 years who were referred to Shahid Rajayie and Ayatollah Rouhani health care centers, Babol University of medical sciences, for menopausal symptoms, filled an informed consent, a checklist including menopause symptoms and the European organization for research and treatment of cancer quality of life (EORTC QLQ-C30) questionnaire. Based on scoring criteria, each of the scale scores in the mentioned questionnaires was determined using SPSS 18 software. In this study, hot flashes and anxiety were the most prevalent symptoms in women with breast cancer. QOL in 36.3% of patients was evaluated as good. 6.3% of patients had physical dysfunction, 2.5%   had role dysfunction, 16.3% had excitement dysfunction, 2.5 % had cognitive dysfunction and 3.8% had social dysfunction. The worst condition was related to the economic impact of the disease with 25% of patients suffering from this condition.The QOL of patients with a history of breast cancer was better in comparison to other studied societies with a similar culture.}, Keywords = {Quality of life, menopause symptoms, EORTC C30 questionnaire}, volume = {1}, Number = {2}, pages = {84-89}, publisher = {4}, url = {http://ibbj.org/article-1-51-en.html}, eprint = {http://ibbj.org/article-1-51-en.pdf}, journal = {International Biological and Biomedical Journal}, issn = {2423-4478}, eissn = {}, year = {2015} }