ORIGINAL_ARTICLE The aim of this study was to compare antioxidant levels of saliva in patients with cirrhosis and liver transplantation. This study was carried out on 45 subjects referred to the Gastroenterohepatology Clinic of Dicle University Medical Faculty. These subjects were composed of cirrhosis, transplanted patients, and control group with no liver problems. The saliva samples were taken in the morning hours after a fasting period and were then stored at –80 ˚C until assay when they were tested for total antioxidant capacity. The photometric analysis was performed with Erel’s method. The statistical evaluation of the data was made using the Kruskal Wallis and Mann-Whitney tests. The total antioxidant level in saliva was significantly lower in patients with cirrhosis (P < 0.05). The post-transplant and control groups were statistically similar in terms of total antioxidant level. Our data suggest that dental caries and increased periodontal problems in cirrhosis may be related to the change in total antioxidant level in saliva. However, further studies are needed to clarify this issue. http://ibbj.org/article-1-250-en.pdf 2023-07-03 0 0 Liver disease liver transplantation oral health saliva Suzan Cangul suzanbali@outlook.com 1 Department of Restorative Dentistry, Faculty of Dentistry, Dicle University, Diyarbakir,Turkey. AUTHOR Begum Erpacal begumerpacal@gmail.com 2 Department of Restorative Dentistry, Faculty of Dentistry, Dicle University, Diyarbakir,Turkey. AUTHOR Ozkan Adıguzel dentamania21@hotmail.com 3 Department of Endodontics, Faculty of Dentistry, Dicle University, Diyarbakir, Turkey. AUTHOR Ibrahim Kaplan dribrahimkaplan@hotmail.com 4 Department of Biochemistry, Faculty of Medicine, Dicle University, Diyarbakir, Turkey. AUTHOR Musa Acarturk m.acarturk@outlook.com 5 Department of Restorative Dentistry, Faculty of Dentistry, Dicle University, Diyarbakir,Turkey AUTHOR Omer Satıcı omrsstc@gmail.com 6 Department of Biostatistics, Faculty of Medicine, Dicle University, Diyarbakir, Turkey. AUTHOR

ORIGINAL_ARTICLE Treatment of diabetic ulcers is associated with a failure in wound healing. While collagen dressing was applied effectively in wound healing, today, advanced dressing designs that can accelerate healing has received attention. Tissue homogenates glycolipoprotein (G-90) contains some growth factors that can participate in healing. The present study examined the wound healing effects of fish scale collagen sponge along with G-90 on sutured incisions in diabetic rats. G-90 was isolated from earthworm (Eisenia foetida). Type 1 collagen was purified from fish scales and lyophilized in sponge form. The sponges were immersed in 10 ng of G- 90. The efficacy of collagen sponge/G-90 was evaluated on sutured incisions in STZ-induced diabetic rats on days 4, 8, 14, and 18 through a morphological and histological approach. The results demonstrated that collagen sponge/G-90 is effective as a wound healing accelerator all days after wounding. Re-epithelialization and angiogenesis were significantly better in the treated group with collagen sponge/G-90 (P≤0.05). Experimental data demonstrated that collagen sponge/G-90 increased fibroblast proliferation, vascularization, collagen synthesis, and collagen fibril diameters. Considering the existence of many growth factors in G-90 and the role of collagen in the extracellular matrix, we conclude that the collagen sponge/G-90 could be a natural mixture for the management of wound healing. Additional studies are proposed to approve it as a wound-healing agent. http://ibbj.org/article-1-277-en.pdf 2024-02-29 0 0 collagen sponge G-90 diabetic rat earthworm wound healing Maryam M. Elmi mitra_elmi2002@yahoo.com 1 Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran AUTHOR Fatemeh Elmi f.elmi@muz.ac.ir 2 Department of Marine Chemistry, Faculty of Marine & oceanic sciences, University of Mazandaran, Babolsar, Iran AUTHOR Chiman Ghaderi chiman.ghaderi9775@gmail.com 3 Department of Radiation Technology, Paramedical Faculty, Babol University of Medical Sciences, Babol, Iran AUTHOR Farideh Feizi feizi.dr@gmail.com 4 Department of Anatomical Science, and Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Science, Babol, Iran AUTHOR