ORIGINAL_ARTICLE Background: Injectable Contraceptive is fourth most popular family planning method worldwide after female sterilization, intra uterine contraceptive device & oral contraceptive. Postpartum contraception is crucial for health of women. METHOD:- This was retrospective study from 1 st Jan 2020 to 31st August 2021 at tertiary care teaching hospital in pune Aim of study was to know demographic details of DMPA (Depot Metroxy Progesterone Acetate) users, side effects & compliance of Inj DMPA. Medical record of 223 women who opted for Inj DMPA after counseling regarding contraceptive options was studied. RESULTS:- Most common side effect observed in Inj DMPA users was menstrual disorder irregular bleeding 62.3% followed by weight gain, amenorrhea & headache in 9.4%,1.7% & 1.3% women respectively. 24.66% women were para one while majority of DMPA users belonged to 21 to 25 years of age group. CONCLUSION:- MPA is highly effective, safe, long term reversible contraceptive option. Proper counseling if done before & after administration of Inj DMPA lead to better patient compliance http://ibbj.org/article-1-293-en.pdf 2024-06-11 0 0 DMPA postpartum contraception family planning Swati Gurav swati.gurav2009@gmail.com 1 BJGMC PUNE AUTHOR Uma Wankhede drumawankhede@rediffmail.com 2 BJGMC PUNE AUTHOR

ORIGINAL_ARTICLE This study assessed the prevalence of Neutropenic sepsis among cancer patient attending Obafemi Awolowo University Teaching Hospital, Ile Ife, Osun State, Nigeria, the study also assesses the socio demographic factors influencing the prevalence of neutropenic sepsis among cancer patients, investigates the relationship between nutritional status and the prevalence of neutropenic sepsis among cancer patients, analyzes the type of cancers, assessed the risk factors and determines the nutritional status.      A total of two hundred (200) questionnaires were used to collect data from the medical records of 200 patients with reference to their case files available in the health record department. The data collection was done daily for three weeks and descriptive statistical techniques such as mean, frequency and percentage, Chi- square were used to analyze the findings of the study.    The overall prevalence of Neutropenic sepsis was 60.0%, it was highest in female (30.5%), in married (30.5%), 27.5% in aged 1-20 years (p= 0.019), 25.5 % in students ( p= 0.002), 23.0% among patients with tertiary education (p=0.024), 36.0% among patients that practice Christianity (p= 0.010), 48.0%  among Yoruba (p= 0.000), the highest 23.0% Neutropenic sepsis was recorded in Leukaemia (p= 0.000), followed by 21.0% in Carcinoma (p= 0.000), 6.5% in Lymphoma (p= 0.001). 4.0% in Renal tumor (p= 0.054), 2.0%  and in Sarcoma ( p=0.000), while 58.0% was recorded in underlying haematological malignancy, followed by 57.5% in intensity chemotherapy ( p= 0.000), and 2.5% in poor nutritional status (p= 0.003), 46.0% was recorded in Coagulopathy (p= 0.000),followed by 41.0% in Physical impairment, 26.5% in Death, 25.0% in organ failure, 5.0% in Neutropenic entercolitis ( p= 0.008) and the least 2.5% in Invasive and atypical infection, and 56.0% was recorded in none malnutrition.      The study concluded that there was high (60.0%) prevalence of Neutropenic sepsis and the main risk factors are poor nutritional status and intensity chemotherapy with Neutropenic entercolitis and Coagulopathy as the complications. Hence, there is the need for health education and create awareness of the disease and its risk factors to all age groups. Keywords: Prevalence, Neutropenic sepsis, Cancer patients, Nigeria   http://ibbj.org/article-1-294-en.pdf 2024-06-11 0 0 NEUTROPENIC SEPSIS CANCER PATIENTS TERTIARY HEALTH INSTITUTION NIGERIA Olarinde Olaniran olarinde71@gmail.com 1 Obafemi Awolowo University AUTHOR Oluwayemisi Olanrewaju Olaniran Olaniranoluwayemisi668@gmail.com 2 Obafemi Awolowo University Teaching Hospital AUTHOR Oluwafemi Oyetoke oyetokeoo@gmail.com 3 Obafemi Awolowo University Teaching Hospital AUTHOR Gboyega Oladipo oladipoao@gmail.com 4 Obafemi Awolowo University Teaching Hospital AUTHOR Bolape Oyekanmi oyekanbolape@gmail.com 5 Adeleke University AUTHOR

ORIGINAL_ARTICLE Alcohol abuse and alcoholism are serious health and socioeconomic problems globally, and chronic alcohol intake can spawn abundant reactive oxygen species (ROS), including superoxide anion radical, hydroxyl radical, and hydrogen peroxide. The study aims to ascertain the impact of an aqueous extract of Citrullus lanatus seed on Liver enzymes, urea and creatinine and following alcohol-induced toxicity in male Wistar rats. The animals were divided into five groups of six animals each, as follows: Group A served as a positive control and received feed and water only; Group B served as a negative control and received alcohol only; Group C received 500 mg/kg of ASCL for 6 weeks; Group D received 3 ml of alcohol for 3 weeks and was treated with 500 mg/kg of ASCL for 6 weeks; and Group E received 3 ml of alcohol for 3 weeks and was treated with 1000 mg/kg of ASCL for 6 weeks. The experiment lasted for 9 weeks, and administration was done through oral gavage. The alcohol-only treated group had a significant difference (p=o.oo) when compared to the normal control, and a significant difference (p=o.oo) was seen in the alcohol-only treated group in comparison with ASCL-treated groups for kidney function, and liver enzymes. Liver enzymes AST, ALT, and ALP in the findings showed a marked increase, indicating an incidence of liver damage. Urea and creatinine were also high in alcohol treated groups. The liver and kidney complications were both attenuated by ASCL, as evidenced by the sharp decline in liver enzymes, urea, and creatinine. ​​​​​​ http://ibbj.org/article-1-298-en.pdf 2024-06-11 0 0 Citrullus lanatus Alcohol-induced toxicity kidney function liver enzymes. Obed Chinwendu Aralu araluobed@gmail.com 1 Dept of physiology, faculty of basic medical science, Abia state uturu AUTHOR A.A Nwankwo azunkwo@gmail.com 2 Dept of physiology, faculty of basic medical science, Abia state uturu AUTHOR Emmanuel Nonso Ezeokafor e.ezeokafor@unizik.edu.ng 3 Department of physiology faculty of basic medical science Nnamdi Azikiwe university AUTHOR chibueze Jeremiah Ike Kingjaycee52@gmail.com 4 department of pharmacology and toxicology, faculty of pharmaceutical science Nnamdi Azikiwe university Ajulu campus. AUTHOR Roy Uchefuna rc.uchefuna@unizik.edu.ng 5 Department of physiology faculty of basic medical science Nnamdi Azikiwe university AUTHOR Kester nwaefulu Ke.nwaefulu@unizik.edu.ng 6 Department of physiology faculty of basic medical science Nnamdi Azikiwe university AUTHOR Kelechi Collins Onwuka onwukakelechi@gmail.com 7 Department of physiology faculty of basic medical science Abia state uturu AUTHOR Augustine wisdom Ehimen augustinewisdom5@gmail.com 8 department of pharmacology and toxicology faculty of pharmaceutical science. AUTHOR Chikwesiri Emmanuel Onyema cemmanuelonyema@gmail.com 9 Department of physiology faculty of basic medical science Nnamdi Azikiwe university AUTHOR