4 International Biological and Biomedical Journal 2423-4478 8 2 2022 7 1 0 0 FA http://ibbj.org/article-1-295-en.html http://ibbj.org/article-1-295-en.docx

4 International Biological and Biomedical Journal 2423-4478 8 2 2022 7 1 Application of Limbal stem cells for regenerative therapy in corneal diseases 0 0 EN Seyed Ahmad Rasoulinejad Department of Ophthalmology, School of Medicine, Babol University of Medical Sciences, Babol, IR, Iran rasolisa2@gmail.com N Nooshin Sarreshtehdari Student Research Committee, Qazvin University of Medical Sciences, Qazvin, IR, Iran. nooshin.sar20@gmail.com N Amir Reza Mafi Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IR, Iran. amirrezamafi1992@gmail.com Y Transparency of the cornea as a clear window on the front surface of the eye is an important issue in visual system that a number of ocular surface diseases affect this. The human ocular surface is constructed by two various types of epithelia: the corneal epithelium in center and the conjunctival epithelium that surrounds this. These two epithelia are separated by limbal epithelium which is known as a major source of stem cells. The limbal stem cells (LSCs) provide the source of corneal epithelial renewal and also provide a promising approach to treat chronic epithelial defects on the corneal surface. Therefore, this review summarizes the current knowledge regarding to cornea and ocular surface diseases with special focusses on stem-cell-based therapeutic methods to improve and restore sight in affected patients.   Limbal stem cell, Ocular surface disease, corneal homeostasis http://ibbj.org/article-1-276-en.html http://ibbj.org/article-1-276-en.docx