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:: Volume 4, Issue 3 (Int Biol Biomed J 2018) ::
IBBJ 2018, 4(3): 126-135 Back to browse issues page
Quorum Sensing in Microbial Virulence
Mohammed Z. Al-Khayyat *
Biology Department, College of Education for Pure Sciences, University of Mosul, Mosul City, Iraq. , mzsaeed19@hotmail.com
Abstract:   (4468 Views)
Cell-to cell communication occurs via a signaling pathway referred to as quorum sensing. There are four main types of these systems according to the chemical nature of signal molecules used by microorganisms to elicit expression of target genes in response to environmental stimuli or need of microbial communities. Type I system acts by using acyl homoserine lactones as signals to trigger the expression of virulence genes in Pseudomonas aeruginosa and members of the Enterobacteriacae family. Other groups of bacteria possess a second system which uses certain furanones as a universal language among different species. Pathogenic Shigella spp., Salmonella, and Escherichia coli rely on catecholamines of the human host for inducing a third quorum sensing system in infection. Short cyclic peptides act mainly in Staphylococcus spp. and Enteroccocus faecalis to activate a forth system involved in their pathogenicity. Therefore, it is essential to analyze these systems for the design of antimicrobials that could eliminate pathogens or abolish their harmful activities. 
Keywords: Autoinducer, LuxI-LuxR homologues, LuxS, pathogenicity
Full-Text [PDF 543 kb]   (1404 Downloads)    
Type of Study: Mini Review | Subject: Molecular & Cellolar
Received: 2018/07/8 | Accepted: 2018/07/26 | Published: 2018/08/24
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Al-Khayyat M Z. Quorum Sensing in Microbial Virulence. IBBJ. 2018; 4 (3) :126-135
URL: http://ibbj.org/article-1-184-en.html

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Volume 4, Issue 3 (Int Biol Biomed J 2018) Back to browse issues page
International Biological and Biomedical Journal
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