en Other Other Original Article Original Article <div style="text-align: justify;"><span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif">Nitrogen-containing compounds, specifically benzimidazole derivatives, represent a significant class of molecules with diverse biological properties that have garnered considerable attention in medicinal chemistry. In this study, two 2-substituted benzimidazoles were successfully synthesized using a boric acid-catalyzed method. The resulting products demonstrated good yields and sharp melting points. The structures of the synthesized compounds were elucidated using Fourier-transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy, including both proton (&sup1;H-NMR) and carbon (&sup1;&sup3;C-NMR) analyses.The compounds were evaluated for their alpha-glucosidase inhibitory activity and antioxidant properties. Both compounds exhibited notable antidiabetic and antioxidant activities. Notably, the compound designated as BL24 demonstrated the highest alpha-glucosidase inhibitory activity and radical scavenging properties. These experimental results indicate that benzimidazoles possess effective antidiabetic and antioxidant potential.</span></span></span></span></div> Benzimidazole, Antioxidant, Alpha-Glucosidase, Oxidative Stress, Diabetes Mellitus 0 0 http://ibbj.org/browse.php?a_code=A-10-424-1&slc_lang=en&sid=1 Ibrahim Gidado ibrahimgidado74@gmail.com 10031947532846004375 10031947532846004375 Yes Federal College of Education, Yola Abdullahi Yunusa Idris ndagiginda@gmail.com 10031947532846004376 10031947532846004376 No Ahmadu Bello University, Zaria Asmau Nasir Hamza hamza.kyauta.asmau@gmail.com 10031947532846004377 10031947532846004377 No Ahmadu Bello University, Zaria Aliyu Musa aliyumusa7@gmail.com 10031947532846004378 10031947532846004378 No Ahmadu Bello University, Zaria Maryam Abdullahi maryamabkif3@gmail.com 10031947532846004379 10031947532846004379 No Ahmadu Bello University, Zaria Ahmadu Jibril darahmadu@gmail.com 10031947532846004380 10031947532846004380 No Ahmadu Bello University, Zaria Lukman Hassan Ali hlukmanali@gmail.com 10031947532846004381 10031947532846004381 No Ahmadu Bello University, Zaria Jimoh Yusuf jimyus1@gmail.com 10031947532846004382 10031947532846004382 No Ahmadu Bello University, Zaria