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:: دوره 3، شماره 4 - ( 5-1396 ) ::
جلد 3 شماره 4 صفحات 157-161 برگشت به فهرست نسخه ها
Treacher Collins Syndrome
چکیده:   (5663 مشاهده)
Treacher Collins syndrome (TCS) is a genetic disease that alters the development of bones and other tissues in the face, and presents variable expressivity. At least three genes TCOF1, POLR1D, and POLR1C were recognized to be at the origin of this syndrome which may be inherited through either an autosomal dominant or autosomal recessive pattern. TCS changes can be divided into otological, ophthalmic and dental malformations. Dental abnormalities occur in 60% of cases and may appear as  tooth agenesis, enamel opacities, widely-spaced teeth, skeletal open bite, distalization of the mandible, bird profile, ectopic eruption of maxillary first molars, improper positioning of the teeth and jaw, and hypoplasia of the mandible jaw. Receding chin and other changes in face structure can be corrected by plastic surgery. As multiple body systems are affected in TCS, long-term follow-up care and the collaboration of a multidisciplinary team care is necessary in order to achieve better physical and psychosocial performances.
     
نوع مطالعه: Mini Review | موضوع مقاله: Genetics & Disease
دریافت: 1396/1/25 | پذیرش: 1396/4/10 | انتشار: 1396/6/4
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Vesna A. Treacher Collins Syndrome. IBBJ. 2017; 3 (4) :157-161
URL: http://ibbj.org/article-1-118-fa.html

Treacher Collins Syndrome. . 1396; 3 (4) :157-161

URL: http://ibbj.org/article-1-118-fa.html



دوره 3، شماره 4 - ( 5-1396 ) برگشت به فهرست نسخه ها
International Biological and Biomedical Journal
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