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:: دوره 3، شماره 3 - ( 3-1396 ) ::
جلد 3 شماره 3 صفحات 105-111 برگشت به فهرست نسخه ها
Consensus Molecular Subtypes of Colorectal Cancer and their Clinical Implications
چکیده:   (6356 مشاهده)

The colorectal cancer (CRC) subtyping consortium has unified six independent molecular classification systems, based on gene expression data, into a single consensus system with four distinct groups, known as the consensus molecular subtypes (CMS); clinical implications are discussed in this review based on articles relevant to the CMS of CRC indexed in PubMed as well as the authors’ own published data. The CMS were determined and correlated with epigenomic, transcriptomic, microenvironmental, genetic, prognostic and clinical characteristics. The CMS1 subtype is immunogenic and hypermutated. CMS2 tumors are activated by the WNT-β-catenin pathway and have the highest overall survival. CMS3 feature a metabolic cancer phenotype and CMS4 cancers have the worst survival and have a strong stromal gene signature. The CMS of CRC may better inform clinicians of prognosis, therapeutic response, and potential novel therapeutic strategies.

     
نوع مطالعه: Mini Review | موضوع مقاله: Cancer
دریافت: 1396/1/29 | پذیرش: 1396/2/21 | انتشار: 1396/3/23
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Thanki K, Edward Nicholls M, Gomez G, Gajjar A, James Senagore A, Rashidi L, et al . Consensus Molecular Subtypes of Colorectal Cancer and their Clinical Implications. IBBJ. 2017; 3 (3) :105-111
URL: http://ibbj.org/article-1-123-fa.html

Consensus Molecular Subtypes of Colorectal Cancer and their Clinical Implications. . 1396; 3 (3) :105-111

URL: http://ibbj.org/article-1-123-fa.html



دوره 3، شماره 3 - ( 3-1396 ) برگشت به فهرست نسخه ها
International Biological and Biomedical Journal
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