Identification of a Rare Synonymous Beta Globin Mutation, HBB:c.180G>A codon 59 (G>A) in an Iranian Patient
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چکیده: (8473 مشاهده) |
Beta thalassemia is the most common autosomal recessive disorder. The present study reports a rare β globin gene mutation, HBB: c.180G>A: codon 59 (AAG/AAA), in a patient from Gilan province, northern Iran. Nucleotide sequencing of amplified DNA belonging to a 35 years old man presenting mild hypochromia revealed a synonymous mutation due to a G>A conversion at the third position of codon 59 of the beta globin gene. The haplotype combination of 2 restriction enzyme sites in beta globin cluster was determined for this mutation. To our knowledge, this is the first article reporting a synonymous mutation at codon 59 (G>A) among the Iranian population highlighting once again the high heterogeneity of this population. |
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نوع مطالعه: Case Report |
موضوع مقاله:
Genetics & Disease دریافت: 1395/4/17 | پذیرش: 1395/4/19 | انتشار: 1395/5/27
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