International Biological and Biomedical Journal
IBBJ
Medical Sciences
http://ibbj.org
1
admin
2423-4478
8
7
14
2423
13
en
jalali
1394
6
1
gregorian
2015
9
1
1
3
online
1
fulltext
en
Clinical Value of Toll Like Receptor 4 and CD14 in Children with Acute Lower Respiratory Tract Infection
Clinical Medicine
Clinical Medicine
Original Article
Original Article
<p dir="ltr" style="text-align: justify;">Toll like receptors (TLRs) with a myeloid differentiation antigen (CD14) recognize and bind various structures from invading microbes and then trigger cell activation. They initiate a variety of effectors' functions, including cytokine secretion, proliferation, co-stimulation or phagocyte maturation. The aim of this study was to evaluate Toll-like receptor 4 (TLR4) and CD14 expression in children with acute lower respiratory tract infections and their relation to severity. The study was carried on 50 children under 3 years of age; 25 of them with lower respiratory tract infection (LRTI) with mean age 11.9± 6.7 months, the other 25 children were healthy controls, age and sex matched. TLR4 and CD14 expression were assessed in both case and control groups. There was no statistical significant difference between cases and controls regarding the mean TLR4 level. mCD14 level among cases was significantly higher than that of the control group with more increase in bacterial LRTI. There was a positive correlation between CD14 with TLC and ESR in bacterial group. There was a positive correlation between respiratory distress severity with CD14, TLC, and ESR levels in patients group. TLR4 was not involved in the development of lower respiratory tract infection in the studied cases. mCD14 might be involved in the development of LRTI, and changes in mCD14 expression are parallel with the levels of TLC and acute phase reactants including CRP, ESR and with respiratory distress severity.</p>
Respiratory tract infection, CD14, toll like receptor
90
97
http://ibbj.org/browse.php?a_code=A-10-89-1&slc_lang=en&sid=1
Houriah
Ahmed Allam
manal24969@gmail.com
10031947532846001767
10031947532846001767
No
Manal
Abd EL-Salam
houra_allam@yahoo.com
10031947532846001768
10031947532846001768
Yes
Amany
mohammad
amanyped@yahoo.com
10031947532846001769
10031947532846001769
No
Alshaymaa
Gamal Aboulkhair
shimaa.gamal@yahoo.com
10031947532846001770
10031947532846001770
No