International Biological and Biomedical Journal
IBBJ
Medical Sciences
http://ibbj.org
1
admin
2423-4478
8
7
14
2423
13
en
jalali
1395
9
1
gregorian
2016
12
1
2
4
online
1
fulltext
en
Analgesic and Anti-inflammatory Activity of Physalis angulata Linn. (Solanaceae) Leaf Methanolic Extract in Swiss Albino Mice
Pharmacology
Pharmacology
Original Article
Original Article
<p style="text-align: justify;">Physalis angulata is a medicinal plant used for the treatment of malaria, ulcer, pains and other diverse ailments. The present study evaluated the analgesic and anti-inflammatory activity of methanolic leaf extract of the plant. Acetic acid-induced abdominal contraction or writhing analgesic models in Swiss albino mice (13-23g) were used for studying analgesic activity of the leaf extract. 200, 300 and 400 mg/kg body weight of the extract were administered intraperitoneally. Analgesic activities of the extract were compared with standard reference drug ibuprofen (100 mg/kg) and negative control. The plant extract showed a significant dose dependent analgesic effect, with 72.7% inhibition at 400 mg/kg compared to that of the 100 mg/kg standard drug ibuprofen which showed 21.2% inhibition (P< 0.05). The anti-inflammatory activity of the extract against carrageenan-induced paw edema was also dose-dependent with 62.71% inhibition at 400 mg/kg when compared to that of the standard drug with 34.31% inhibition. The study showed that P. angulata was effective in pain reduction (analgesia) and acted as a good anti-inflammatory agent, which supports the claim in traditional medicine.</p>
Physalis angulata, analgesic, anti-inflammatory, Carrageenan
167
170
http://ibbj.org/browse.php?a_code=A-10-106-3&slc_lang=en&sid=1
Cletus Anes
Ukwubile
doccletus@yahoo.com
10031947532846002315
10031947532846002315
Yes
Ikpefan Emmanuel
Oise
ikpefan@delsu.edu.ng
10031947532846002316
10031947532846002316
No