International Biological and Biomedical Journal
IBBJ
Medical Sciences
http://ibbj.org
1
admin
2423-4478
8
7
14
2423
13
en
jalali
1395
9
1
gregorian
2016
12
1
2
4
online
1
fulltext
en
In Vitro Antidiabetic Activity of Ethanolic Leaf Extract of Bruguiera Cylindrica L. – Glucose Uptake by Yeast Cells Method
Pharmacology
Pharmacology
Original Article
Original Article
<p style="text-align: justify;">The current epidemic of diabetes indicates the need of proper and effective medications that are limited in their potency to have many side effects. Thus, introduction of alternative and complementary medicine is now in picture. The main objective of this study was to analyze the rate of glucose transport across cell membrane in yeast cells system in the presence of the ethanolic extract of Bruguiera cylindrical leaves. After the treatment of the yeast cells with the ethanolic extract of B. cylindrica, the glucose uptake did not increase in a dose dependent manner. The increase of percentage of glucose uptake by the yeast cells was found in the glucose concentrations varying from 5 to 25 mM in the presence of 1 and 5 mg/ml of B. cylindrical ethanolic extract (BCEE). The BCEE can serve as a therapeutic agent and can be used as potential source of novel bioactive compounds for treating type 2 diabetes mellitus.</p>
Bruguiera cylindrica, ethanolic extract, glucose uptake, antidiabetic activity
171
175
http://ibbj.org/browse.php?a_code=A-10-164-1&slc_lang=en&sid=1
Revathi
Pitchaipillai
reva1923@gmail.com
10031947532846002317
10031947532846002317
Yes
Thirumalaikolundusubramanian
Ponniah
umatks@gmail.com
10031947532846002318
10031947532846002318
No