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:: Volume 3, Issue 3 (Int Biol Biomed J 2017) ::
IBBJ 2017, 3(3): 105-111 Back to browse issues page
Consensus Molecular Subtypes of Colorectal Cancer and their Clinical Implications
Ketan Thanki1 , Michael Edward Nicholls1 , Guillermo Gomez1 , Aakash Gajjar1 , Anthony James Senagore1 , Laila Rashidi1 , Suimin Qiu2 , Csaba Szabo3 , Mark Richard Hellmich1 , Celia Chao * 4
1- Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
2- Department of Surgical Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
3- Department of Anesthesiology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
4- Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. , cechao@utmb.edu
Abstract:   (9311 Views)

The colorectal cancer (CRC) subtyping consortium has unified six independent molecular classification systems, based on gene expression data, into a single consensus system with four distinct groups, known as the consensus molecular subtypes (CMS); clinical implications are discussed in this review based on articles relevant to the CMS of CRC indexed in PubMed as well as the authors’ own published data. The CMS were determined and correlated with epigenomic, transcriptomic, microenvironmental, genetic, prognostic and clinical characteristics. The CMS1 subtype is immunogenic and hypermutated. CMS2 tumors are activated by the WNT-β-catenin pathway and have the highest overall survival. CMS3 feature a metabolic cancer phenotype and CMS4 cancers have the worst survival and have a strong stromal gene signature. The CMS of CRC may better inform clinicians of prognosis, therapeutic response, and potential novel therapeutic strategies.

Keywords: Colorectal cancer, molecular subtypes, clinical, classification
Full-Text [PDF 340 kb]   (7526 Downloads)    
Type of Study: Mini Review | Subject: Cancer
Received: 2017/04/18 | Accepted: 2017/05/11 | Published: 2017/06/13
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Thanki K, Edward Nicholls M, Gomez G, Gajjar A, James Senagore A, Rashidi L, et al . Consensus Molecular Subtypes of Colorectal Cancer and their Clinical Implications. IBBJ 2017; 3 (3) :105-111
URL: http://ibbj.org/article-1-123-en.html


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Volume 3, Issue 3 (Int Biol Biomed J 2017) Back to browse issues page
International Biological and Biomedical Journal
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