[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 5, Issue 3 (Int Biol Biomed J (In press) 2019) ::
IBBJ 2019, 5(3): 0-0 Back to browse issues page
Assessment of Thyroid Function in Workers Occupationally Exposed to Gasoline and Paint Products in Anambra Central of Nigeria
Samuel C. Meludu1, Chidiebere E. Ugwu2, Ogechukwu S. Ogbuowelu1, Patrick O. Manafa1, Ogbonnia Ekuma-Okereke *3
1- Department of Medical Laboratory Science, Faculty of Health Sciences & Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
2- Department of Human Biochemistry, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
3- Department of Medical Laboratory Science, Faculty of Health Sciences & Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria. , Ogbonniaekuma@gmail.com
Abstract:   (234 Views)
Hydrocarbons (benzene, toluene, ethyl benzene and xylene (BTEX) found in gasoline and organic solvents are ubiquitous in the environment, and are known to have toxic effects in human system. This study therefore investigated the thyroid function of workers occupationally exposed to gasoline and paint products using TSH, T3 and T4 as markers. A total of 162 subjects were recruited for this study; (56 gasoline pump attendants and 56 paint factory workers) and 50 subjects as control. Blood sample was collected from each subject and thyroid function tests (T3, T4 and TSH), were assayed using Enzyme linked immunosorbent assay (ELISA) techniques. The mean values of TSH was significantly lower in the gasoline workers and painters compared to the control subjects (1.73±0.89, 1.66±0.84 Vs 2.09±1.06µIU/ml; F= 3.169, p<0.05). The mean values of T4 was significantly lower in gasoline workers and painters when compared to the control subjects (9.09±1.87, 9.63±1.90 Vs 12.06 ± 1.82µg/dl; F= 37.430, p<0.05). However, the mean levels of T3 was significantly higher in gasoline workers and painters compared to the control subjects (2.56± 0.65, 2.72 ± 0.65 Vs 1.03 ± 0.30ng/ml; F= 161.292, p<0.05). The mean body mass index, systolic and diastolic blood pressures were similar in all the groups. The levels of TSH showed a significant inverse correlation with the duration of exposure in the subjects exposed to gasoline (r=-0.326, p<0.05), whereas the levels of T3 showed a positive significant correlation with the duration of exposure in paint workers (r=0.301; p<0.05). This study demonstrated that both gasoline and paint showed similar effects on the thyroid parameters of the subjects under study, which is suggestive of T3 thyrotoxicosis.
Keywords: Hydrocarbons, Benzene, Toluene, Ethyl benzene, Xylene, thyroid function
     
Type of Study: Original Article | Subject: Clinical Medicine
Received: 2019/09/11 | Accepted: 2019/11/21
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Meludu S C, Ugwu C E, Ogbuowelu O S, Manafa P O, Ekuma-Okereke O. Assessment of Thyroid Function in Workers Occupationally Exposed to Gasoline and Paint Products in Anambra Central of Nigeria . IBBJ. 2019; 5 (3)
URL: http://ibbj.org/article-1-234-en.html


Volume 5, Issue 3 (Int Biol Biomed J (In press) 2019) Back to browse issues page
International Biological and Biomedical Journal
Persian site map - English site map - Created in 0.06 seconds with 32 queries by YEKTAWEB 3949