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:: Volume 5, Issue 3 (Int Biol Biomed J (In press) 2019) ::
IBBJ 2019, 5(3): 0-0 Back to browse issues page
Modulation of Serum Vaspin Level by Diet Regimen in Obese Diabetic Female Patients
Sherif Wagih Mansour *1, Mohammed Saed Tawfiq2, Eman Abd Allah El-Shorbgy3, Abeer Albiomy Khalefa4, Shaimaa Elsayed Hadhoud5
1- Professor of Physiology, Head of physiology department, Faculty of medicine, Zagazig University. , drsherif36@hotmail.com
2- Professor of Physiology, Faculty of medicine, Zagazig University.
3- Professor of Internal medicine , Faculty of medicine, Zagazig University.
4- Professor of Physiology, Faculty of medicine, Zagazig University
5- 5. Ass lecturer of Physiology, Faculty of medicine, Zagazig
Abstract:   (229 Views)
Obesity was associated with high serum vaspin concentrations and increased vaspin mRNA expression in human adipose tissue , insulin resistance, and type II diabetes. However, the mechanisms how vaspin secretion may be linked to deterioration of glucose metabolism and insulin sensitivity are not understood. The aim of this work is to explore the effect of dietary regimen for 6 months on serum vaspin levels in obese diabetic and non diabetic female patients. The study was carried out in Zagazig University Hospital and Obesity management and research unit. The sample size was 40 obese female patients. All participants were screened to determine the eligibility for participation in the study according to specific inclusion and exclusion criteria.Control groups didn't follow any diet plan while mediterrnean diet group followed mediterrnean diet for 6 months. The following parameters were assessed at the beginning and after 6months:body mass index(BMI), waist circumference(WC),Homeostatic model assessment (HOMA), Atherogenic index (AI), creatinine clearance  and circulating levels of vaspin, vitamin D ,Low density lipoprotein (LDL), High density lipoprotein (HDL), Triglyecrides (TG), Total cholesterol  (TC), glucose,insulin,HbA1c, Superoxide dismutase (SOD) and Malondialdehyde (MDA). Mediterrnean diet life style for 6 months resulted in a significant decrease in BMI, WC, HOMA, AI, vaspin, LDL, TG, TC,glucose,insulin,HbA1c  and MDA with a significant increase in HDL,SOD and vitamin D. Elevated  serum vaspin and low Vit D levels  are encountered in obesity. So, vaspin may be used as a novel biomarker for obesity, insulin resistance and Type II DM management.
Keywords: KEY WORDS: Vaspin, Adipokines, Obesity, Type II DM
     
Type of Study: Original Article | Subject: Clinical Medicine
Received: 2019/10/2 | Accepted: 2019/11/21
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Mansour S W, Tawfiq M S, El-Shorbgy E A A, Khalefa A A, Hadhoud S E. Modulation of Serum Vaspin Level by Diet Regimen in Obese Diabetic Female Patients . IBBJ. 2019; 5 (3)
URL: http://ibbj.org/article-1-235-en.html


Volume 5, Issue 3 (Int Biol Biomed J (In press) 2019) Back to browse issues page
International Biological and Biomedical Journal
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