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Pineal and Hypophyseal Responses to Selenium Treatments in Light Deprived Adult Female Wistar Rats
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چکیده: (3674 مشاهده) |
Dark is a generally known potent stimulus for melatonin secretion. Studies have also reported that pineal and hypophyseal endocrine secretions are influenced by nutritional factors. The study was designed to investigate the combined effect of selenium supplementations and light deprivation on pineal and hypophyseal secretions in female Wistar rats. 36 female cyclical Wistar rats were divided into vehicle, high selenium (HS), low selenium (LS), light deprived (LD), LD+HS and LD+LS. Rats were orally administered 150µg/kg and 100µg/kg of sodium selenite for two weeks. While light deprived rats were maintained under 6hr light/18hr dark cycle, other rats were under natural 12hr light/12hr dark cycle. The result showed that light deprivation led to significant decrease (P<0.05) in follicle stimulating hormone (FSH) secretion and a significant increase (P<0.05) in plasma melatonin. Selenium supplementations at both doses also improved luteinizing hormone (LH) secretion but had no effect on plasma prolactin. At high dose of selenium supplementation, there was an increase in melatonin secretion. In light deprived rats, selenium supplementations caused a significant decrease (P<0.05) in melatonin secretion at both doses but there was no significant change in plasma levels of FSH, LH and prolactin. The findings indicate differential responses of pineal and hypophyseal glands to light deprivation and selenium treatments.
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نوع مطالعه: Original Article |
موضوع مقاله:
Clinical Biochemistry
دریافت: 1398/11/6 | پذیرش: 1399/11/29 | انتشار: 1399/11/29
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