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Application of Limbal stem cells for regenerative therapy in corneal diseases
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Seyed Ahmad Rasoulinejad1   , Nooshin Sarreshtehdari2 , Amir Reza Mafi * 3 |
1- Department of Ophthalmology, School of Medicine, Babol University of Medical Sciences, Babol, IR, Iran
2- Student Research Committee, Qazvin University of Medical Sciences, Qazvin, IR, Iran.
3- Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IR, Iran. , amirrezamafi1992@gmail.com |
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Abstract: (1247 Views) |
Transparency of the cornea as a clear window on the front surface of the eye is an important issue in visual system that a number of ocular surface diseases affect this. The human ocular surface is constructed by two various types of epithelia: the corneal epithelium in center and the conjunctival epithelium that surrounds this. These two epithelia are separated by limbal epithelium which is known as a major source of stem cells. The limbal stem cells (LSCs) provide the source of corneal epithelial renewal and also provide a promising approach to treat chronic epithelial defects on the corneal surface. Therefore, this review summarizes the current knowledge regarding to cornea and ocular surface diseases with special focusses on stem-cell-based therapeutic methods to improve and restore sight in affected patients.
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| Keywords: Limbal stem cell, Ocular surface disease, corneal homeostasis |
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Type of Study: Review |
Subject:
Stem Cell
Received: 2022/06/11 | Accepted: 2023/01/27 | Published: 2024/02/27
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