[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 1, Issue 4 (Int Biol Biomed J 2015) ::
IBBJ 2015, 1(4): 128-136 Back to browse issues page
The Impression of Histone Modification and DNA Methylation in Gastric Cancer Development: Molecular Mechanism Approach
Seyedeh Elham Norollahi , Mohamad Taghi Hamidian , Mohaddese Shokravi , Mehrnaz Ajourlou , Ali Akbar Samadani * 1
Abstract:   (2543 Views)

The epigenetic alterations like histone modifications , DNA methylation and others remarkable categories  including nucleosome remodeling and RNA mediated targeting have been strongly investigated  recently .In this way , beside the notable importance of DNA methylation ,the histone modifications are the most important issues in the  tumorogenesis and cancer progression. Moreover, the fluctuations of histone modifications particularly, the dysregulation of histone alterations is engaged directly in carcinogenesis. Conclusively, it is confirmed that aberrant epigenetic modifications along side with chromosomal losses and mutations are involved in cancer progression. Hence, histone modifications and DNA methylation have the impressive abilities and potential to be practical prognostic biomarkers in order to manage all aspects of cancers like diagnosis, controlling and treatment. In this review article, we focus the recent advances of these alterations specially, histone modifications in gastric cancer development.

Keywords: Histone modifications, gastric cancer, DNA methylation, epigenetic
Full-Text [PDF 1311 kb]   (1246 Downloads)    
Type of Study: Review | Subject: Cancer
Received: 2016/07/8 | Accepted: 2016/07/9 | Published: 2016/08/17
Add your comments about this article
Your username or Email:

Write the security code in the box >


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Norollahi S E, Hamidian M T, Shokravi M, Ajourlou M, Samadani A A. The Impression of Histone Modification and DNA Methylation in Gastric Cancer Development: Molecular Mechanism Approach. IBBJ. 2015; 1 (4) :128-136
URL: http://ibbj.org/article-1-58-en.html


Volume 1, Issue 4 (Int Biol Biomed J 2015) Back to browse issues page
International Biological and Biomedical Journal
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3701