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:: Volume 2, Issue 3 (Int Biol Biomed J 2016) ::
IBBJ 2016, 2(3): 127-133 Back to browse issues page
Phytochemical Screening, Antioxidant and Antibacterial Activities of Commiphora kerstingii
Toma Ibrahim * 1, Gidado Gidado , Khan Muluh , Abel Alexander
1- , dalitoma2014@gmail.com
Abstract:   (1578 Views)

Phytochemical screening, antioxidant and antibacterial activities of aqueous and methanolic crude extracts of Commiphora kerstingii leaves were investigated. The antioxidant and antibacterial properties of different solvent extracts of Commiphora kerstingii plant were scrutinized. The phytochemical screening of the various extracts was carried out using standard methods and the results revealed the presence of alkaloids, phenols, tannins, saponins and volatile oils. The antioxidant activity of the extracts was screened using hydrogen peroxide free radical scavenging assay to obtain an IC50 value. The IC50 values of ascorbic acid (standard drug), methanolic and aqueous extracts were 0.49, 0.33 and 0.54 mg/ml, respectively. The antibacterial activity was tested using Streptococcus mutans, Escherichia coli, and Proteus mirabilis. The results showed reasonable zones of inhibition at almost all concentrations used against tested organisms; with Streptococcus mutans being most inhibited (diameter of inhibition of 23 mm) and Escherichia coli being least inhibited (3mm) with the methanolic extract. In contrast, Escherichia coli was the most inhibited (8 mm) and Streptococcus mutans showed least inhibition (3 mm) in the presence of aqueous extract. Minimum inhibitory concentration (MIC) was 0.05 g/ml on the average. The results, thus support the use of the plant traditionally to treat dental caries, diarrhea, and urinary tract infection, and suggest its usage in the formulation of new antioxidant and antibacterial drugs.

Keywords: Commiphora kerstingii, Streptococcus mutans, Escherichia coli, Proteus mirabilis, antioxidant activity
Full-Text [PDF 932 kb]   (1005 Downloads)    
Type of Study: Original Article | Subject: Medical Biotechnology
Received: 2016/11/15 | Accepted: 2016/12/1 | Published: 2016/12/5
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Ibrahim T, Gidado G, Muluh K, Alexander A. Phytochemical Screening, Antioxidant and Antibacterial Activities of Commiphora kerstingii. IBBJ. 2016; 2 (3) :127-133
URL: http://ibbj.org/article-1-76-en.html


Volume 2, Issue 3 (Int Biol Biomed J 2016) Back to browse issues page
International Biological and Biomedical Journal
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