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:: Volume 3, Issue 1 (Int Biol Biomed J 2017) ::
IBBJ 2017, 3(1): 1-7 Back to browse issues page
Impact of Genetic Variants in Mir-122 Gene and its Flanking Regions on Hepatitis B Risk
Sadegh Fattahi1, Mohammad Karimi Alivije2, Farhang Babamahmoodi3, Masomeh Bayani4, Mahmoud Sadeghi-Haddad-Zavareh4, Mohsen Asouri1, Maryam Lotfi1, Galia Amirbozorgi1, Morteza Gholami1, Haleh Akhavan-Niaki *5
1- Cellular and Molecular Department
2- Department of Infectious Diseases
3- Department of Antimicrobial Resistance Research Center
4- Infectious Diseases and Tropical Medicine Research Center
5- Department of Genetics , Halehakhavan@yahoo.com
Abstract:   (6779 Views)

MicroRNAs are small non coding RNAs that are involved in gene expression regulation. Mir-122 was reported to inhibit hepatitis B virus (HBV), but little is known about the role of mir-122 polymorphisms on HBV infection development. This present study aimed to investigate the association between single nucleotide polymorphisms (SNPs) in mir-122 gene region with HBV infection. Study cases were HBV positive and negative individuals. 67 SNPs in mir-122 gene and its flanking regions were analyzed by sequencing method. mirVas software was used to assay the impact of polymorphisms on the secondary structure of mir-122 gene. 66 out of 67 studied SNPs were monomorphic and rs 17669 was the only polymorphic SNP in the studied population, with the T allele being four times more frequent than the C allele. However, there was no significant difference in alleles distribution between patient and control groups. Rs 17669 variant located near the mir-122 gene showed the highest impact for centroid, maximal expected accuracy, and minimal free energy structures in the arm, flank, and flank regions of mir-122, respectively. Therefore, rs17669 variant was predicted to exert an effect on mir-122 stability. The study of larger samples from different ethnicities may help to find a possible association between rs17669 genotype and HBV infection.

Keywords: Mir-122, HBV, single nucleotide polymorphism, rs17669, mirVas
Full-Text [PDF 668 kb]   (1810 Downloads)    
Type of Study: Original Article | Subject: Other
Received: 2016/11/27 | Accepted: 2016/12/29 | Published: 2017/01/14
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Fattahi S, Karimi Alivije M, Babamahmoodi F, Bayani M, Sadeghi-Haddad-Zavareh M, Asouri M, et al . Impact of Genetic Variants in Mir-122 Gene and its Flanking Regions on Hepatitis B Risk. IBBJ. 2017; 3 (1) :1-7
URL: http://ibbj.org/article-1-88-en.html

Volume 3, Issue 1 (Int Biol Biomed J 2017) Back to browse issues page
International Biological and Biomedical Journal
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