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:: Volume 2, Issue 4 (Int Biol Biomed J 2016) ::
IBBJ 2016, 2(4): 167-170 Back to browse issues page
Analgesic and Anti-inflammatory Activity of Physalis angulata Linn. (Solanaceae) Leaf Methanolic Extract in Swiss Albino Mice
Cletus Anes Ukwubile *1, Ikpefan Emmanuel Oise
1- , doccletus@yahoo.com
Abstract:   (1165 Views)

Physalis angulata is a medicinal plant used for the treatment of malaria, ulcer, pains and other diverse ailments. The present study evaluated the analgesic and anti-inflammatory activity of methanolic leaf extract of the plant. Acetic acid-induced abdominal contraction or writhing analgesic models in Swiss albino mice (13-23g) were used for studying analgesic activity of the leaf extract. 200, 300 and 400 mg/kg body weight of the extract were administered intraperitoneally. Analgesic activities of the extract were compared with standard reference drug ibuprofen (100 mg/kg) and negative control. The plant extract showed a significant dose dependent analgesic effect, with 72.7% inhibition at 400 mg/kg compared to that of the 100 mg/kg standard drug ibuprofen which showed 21.2% inhibition (P< 0.05). The anti-inflammatory activity of the extract against carrageenan-induced paw edema was also dose-dependent with 62.71% inhibition at 400 mg/kg when compared to that of the standard drug with 34.31% inhibition. The study showed that P. angulata was effective in pain reduction (analgesia) and acted as a good anti-inflammatory agent, which supports the claim in traditional medicine.

Keywords: Physalis angulata, analgesic, anti-inflammatory, Carrageenan
Full-Text [PDF 700 kb]   (733 Downloads)    
Type of Study: Original Article | Subject: Pharmacology
Received: 2016/11/18 | Accepted: 2016/12/27 | Published: 2017/01/5
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Ukwubile C A, Oise I E. Analgesic and Anti-inflammatory Activity of Physalis angulata Linn. (Solanaceae) Leaf Methanolic Extract in Swiss Albino Mice. IBBJ. 2016; 2 (4) :167-170
URL: http://ibbj.org/article-1-89-en.html


Volume 2, Issue 4 (Int Biol Biomed J 2016) Back to browse issues page
International Biological and Biomedical Journal
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