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:: دوره 3، شماره 1 - ( 10-1395 ) ::
جلد 3 شماره 1 صفحات 1-7 برگشت به فهرست نسخه ها
Impact of Genetic Variants in Mir-122 Gene and its Flanking Regions on Hepatitis B Risk
چکیده:   (6780 مشاهده)

MicroRNAs are small non coding RNAs that are involved in gene expression regulation. Mir-122 was reported to inhibit hepatitis B virus (HBV), but little is known about the role of mir-122 polymorphisms on HBV infection development. This present study aimed to investigate the association between single nucleotide polymorphisms (SNPs) in mir-122 gene region with HBV infection. Study cases were HBV positive and negative individuals. 67 SNPs in mir-122 gene and its flanking regions were analyzed by sequencing method. mirVas software was used to assay the impact of polymorphisms on the secondary structure of mir-122 gene. 66 out of 67 studied SNPs were monomorphic and rs 17669 was the only polymorphic SNP in the studied population, with the T allele being four times more frequent than the C allele. However, there was no significant difference in alleles distribution between patient and control groups. Rs 17669 variant located near the mir-122 gene showed the highest impact for centroid, maximal expected accuracy, and minimal free energy structures in the arm, flank, and flank regions of mir-122, respectively. Therefore, rs17669 variant was predicted to exert an effect on mir-122 stability. The study of larger samples from different ethnicities may help to find a possible association between rs17669 genotype and HBV infection.

     
نوع مطالعه: Original Article | موضوع مقاله: Other
دریافت: 1395/9/7 | پذیرش: 1395/10/9 | انتشار: 1395/10/25
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Fattahi S, Karimi Alivije M, Babamahmoodi F, Bayani M, Sadeghi-Haddad-Zavareh M, Asouri M, et al . Impact of Genetic Variants in Mir-122 Gene and its Flanking Regions on Hepatitis B Risk. IBBJ. 2017; 3 (1) :1-7
URL: http://ibbj.org/article-1-88-fa.html

Impact of Genetic Variants in Mir-122 Gene and its Flanking Regions on Hepatitis B Risk. . 1395; 3 (1) :1-7

URL: http://ibbj.org/article-1-88-fa.html



دوره 3، شماره 1 - ( 10-1395 ) برگشت به فهرست نسخه ها
International Biological and Biomedical Journal
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