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:: Volume 6, Issue 3 (Int Biol Biomed J (In press) 2020) ::
IBBJ 2020, 6(3): 0-0 Back to browse issues page
Investigation of the therapeutic effect of nicotine and its metabolites on the brain
Amin Ataie Dr *1, Ramin Ataee Dr2, Hossein Khaleghzadeh Dr3
1- department of toxicology and pharmacology , ataieamin@yahoo.com
2- Pharmaceutical sciences research center, Hemoglobinopathy institute
3- department of physiology
Abstract:   (1014 Views)
The effect of Cotinine, active metabolite of nicotine, on Aβ1-42 neurotoxicity was investigated. Cotinine possesses a longer plasma half-life, lower toxicity and it is a partial agonist of the nicotinic acetylcholine receptors (nAChR). Cotinine prolonged the survival of cortical neurons exposed to Aβ1-42. These results indicated that cotinine has a neuroprotective effect by inhibition of the formation of amyloid beta in the brain. The nicotine and its metabolites function in the brain are controversial. In this review, the mechanism of nicotine and the metabolites on neuronal physiology were studied, also their effects on learning and memory were investigated.Some studies indicate the pharmacological action of nicotine in the treatment of Parkinson's disease. There are three nicotine active metabolites that have pharmacological effects in some parts of the brain, such as cotinine, norcotinine, nornicotine, also cotinine, and nornicotine both had beneficial effects in learning and memory without adverse effects.
Keywords: Cotinine, Nicotine, Alzheimer Disease, Parkinson Disease, Cognition, Neuroprotection, Nicotinic Acetyl Choline Receptor
     
Type of Study: Review | Subject: Pharmacology
Received: 2020/07/24 | Accepted: 2020/09/26 | Published: 2021/02/17
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ataie A, ataee R, khaleghzadeh H. Investigation of the therapeutic effect of nicotine and its metabolites on the brain. IBBJ. 2020; 6 (3)
URL: http://ibbj.org/article-1-255-en.html


Volume 6, Issue 3 (Int Biol Biomed J (In press) 2020) Back to browse issues page
International Biological and Biomedical Journal
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