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O-1135: Anticancer Activity of an enzymatic hydrolysate from Chlorella vulgaris on Mouse colon cancer cells
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Zahra Yghoubzadeh *1   , Reza Safari2 |
1- Caspian Sea Ecology Research Center (CSERC), Iranian Fisheries Science Research Institute (IFSRI), Agricultural Research, Education and Extension Organization (AREEO), Sari, Iran , za_yaghoub@yahoo.com
2- Caspian Sea Ecology Research Center (CSERC), Iranian Fisheries Science Research Institute (IFSRI), Agricultural Research, Education and Extension Organization (AREEO), Sari, Iran |
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Abstract: (708 Views) |
Background: Cancer is one of the major causes of mortality in the globe. Several drugs were derived from natural sources such as plants and microorganisms against various types of cancer. Chlorella is a unicellular green alga found in fresh and marine water and is widely used as a food supplement. Chlorella vulgaris protein hydrolysate (CVPH) was tested after being hydrolyzed by pepsin as a gastrointestinal protease.
Methods: The cytotoxic effect on the CT-26 cell line was evaluated using the MTT assay.
Results: The results of toxicity assays showed that the survival rate of the cells was decreased by increasing the concentrations of the peptides (62.5, 125, 250, 500, and 1000 µg/ml). Peptides of <3 kDa molecular weight had a substantial impact on the viability of murine colon cancer cells with an IC50 value of 435 µg/ml.
Conclusions: The results of the present study showed that the Chlorella vulgaris hydrolysates protein obtained showed anti-cancer activities against the murine colon cancer (CT-26) cell line. |
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| Keywords: Peptides, Enzymatic hydrolysate, Anticancer activity, Colon cancer, Chlorella vulgaris |
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Type of Study: Original Article |
Subject:
Other
Received: 2024/03/05 | Accepted: 2024/03/05 | Published: 2024/03/05
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