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دوره 10، شماره 4 - ( 9-1403 ) |
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Benzimidazole Derivatives as Multitarget Agents: Synthesis, Characterization, Invitro Alpha-glucosidase Inhibition and Antioxidants Activity
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چکیده: (604 مشاهده) |
Nitrogen-containing compounds, specifically benzimidazole derivatives, represent a significant class of molecules with diverse biological properties that have garnered considerable attention in medicinal chemistry. In this study, two 2-substituted benzimidazoles were successfully synthesized using a boric acid-catalyzed method. The resulting products demonstrated good yields and sharp melting points. The structures of the synthesized compounds were elucidated using Fourier-transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy, including both proton (¹H-NMR) and carbon (¹³C-NMR) analyses.The compounds were evaluated for their alpha-glucosidase inhibitory activity and antioxidant properties. Both compounds exhibited notable antidiabetic and antioxidant activities. Notably, the compound designated as BL24 demonstrated the highest alpha-glucosidase inhibitory activity and radical scavenging properties. These experimental results indicate that benzimidazoles possess effective antidiabetic and antioxidant potential. |
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نوع مطالعه: Original Article |
موضوع مقاله:
Other
دریافت: 1403/7/8 | پذیرش: 1403/9/3 | انتشار: 1403/10/9
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| ارسال نظر درباره این مقاله |
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Gidado I, Idris A Y, Hamza A N, Musa A, Abdullahi M, Jibril A, et al . Benzimidazole Derivatives as Multitarget Agents: Synthesis, Characterization, Invitro Alpha-glucosidase Inhibition and Antioxidants Activity. IBBJ 2024; 10 (4) URL: http://ibbj.org/article-1-305-fa.html
Benzimidazole Derivatives as Multitarget Agents: Synthesis, Characterization, Invitro Alpha-glucosidase Inhibition and Antioxidants Activity. . 1403; 10 (4) URL: http://ibbj.org/article-1-305-fa.html
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