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Benzimidazole Derivatives as Multitarget Agents: Synthesis, Characterization, Invitro Alpha-glucosidase Inhibition and Antioxidants Activity
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Ibrahim Gidado *1   , Abdullahi Yunusa Idris2 , Asmau Nasir Hamza2 , Aliyu Musa2 , Maryam Abdullahi2 , Ahmadu Jibril2 , Lukman Hassan Ali2 , Jimoh Yusuf2 |
1- Federal College of Education, Yola & Ahmadu Bello University, Zaria , ibrahimgidado74@gmail.com
2- Ahmadu Bello University, Zaria |
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Abstract: (741 Views) |
Nitrogen-containing compounds, specifically benzimidazole derivatives, represent a significant class of molecules with diverse biological properties that have garnered considerable attention in medicinal chemistry. In this study, two 2-substituted benzimidazoles were successfully synthesized using a boric acid-catalyzed method. The resulting products demonstrated good yields and sharp melting points. The structures of the synthesized compounds were elucidated using Fourier-transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy, including both proton (¹H-NMR) and carbon (¹³C-NMR) analyses.The compounds were evaluated for their alpha-glucosidase inhibitory activity and antioxidant properties. Both compounds exhibited notable antidiabetic and antioxidant activities. Notably, the compound designated as BL24 demonstrated the highest alpha-glucosidase inhibitory activity and radical scavenging properties. These experimental results indicate that benzimidazoles possess effective antidiabetic and antioxidant potential. |
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| Keywords: Benzimidazole, Antioxidant, Alpha-Glucosidase, Oxidative Stress, Diabetes Mellitus |
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Full-Text [PDF 749 kb]
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Type of Study: Original Article |
Subject:
Other
Received: 2024/09/29 | Accepted: 2024/11/23 | Published: 2024/12/29
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